Nano-Emulsion vs Liposomal CBD: Which Is Best?

CBD oil and CBD gummies are the two most commonly used forms of CBD. People prefer both forms due to their affordability and comfort. However, there are some problems associated with oral CBD use. Studies suggest that oral CBD has an extremely low bioavailability.

Low bioavailability means very little is reaching your bloodstream or circulation after oral ingestion. That is why people are not getting promised health effects or need to ingest CBD in higher dosages. 

Studies suggest that the bioavailability of orally ingested regular CBD products varies between 13-19%. This means that barely one-fifth of CBD reaches your bloodstream, and the rest is just lost. Although, of course, these statistics must be interpreted cautiously, the bioavailability of CBD can be increased, and it depends much on the carrier oil. For example, using olive oil or MCTs may boost the bioavailability of CBD oils.

There are various ways of boosting bioavailability. For example, one way could be changing the intake route. Vaping may increase stability, but it shortens CBD’s half-life and increases the risk of lung disorders.

Another way is to find novel solutions that are safe and could yet considerably improve CBD’s bioavailability. Thus, some of the ways are producing water soluble CBD. For example, one may create nano-emulsion or liposomal CBD.

These technologies have been around for quite a while, and their pros and cons are well known. However, it appears that creating nano-emulsion is better, as it results in higher solubility, bioavailability, and more stable products—a way preferred by Essentia Pura.

Different Ways to Produce Water-Soluble CBD:

Cannabidiol (CBD) is naturally lipid soluble, which is the prime reason for its poor bioavailability. However, there are many ways of improving its bioavailability. For example, using MCTs as carrier oils may help boost their bioavailability.

Another way could be making it water-soluble. Yes, it is possible to make fats water-soluble. Milk is an excellent example of a naturally occurring emulsion, a water-based produced with suspended fat particles.

The human body absorbs water more readily, as it needs one and a half to two litres of water a day. Therefore, more than 60% of the human body is water. 

There are many ways of making CBD water-soluble, like using liposome technology or creating nano-emulsified liquid CBD concentrate.

Both liposomal technology and nano-emulsions have been well-studied by science, as pharmaceutical manufacturers have extensively tested these methods. 

Studies suggest that liposomal is quite a good technology for some specific medications, though it may not be a good choice for CBD. 

In both these technologies, manufacturers encapsulate lipid soluble CBD in a water-soluble structure, thus creating an amphipathic structure. It means that both of these technologies create structures with a water-soluble outer layer. 

Nano-emulsions have better bioavailability in many cases due to smaller particle sizes and are simpler to produce. Hence, using this technology is a better choice for CBD. On the other hand, liposomal technology is more complex and is better suited for specific drugs.

In nano-emulsion, the liquid lipid core is covered by a surfactant monolayer, making it readily absorbable by the body and yet stable. It is the way in which nature tries to boost the bioavailability of some fat-soluble vitamins and other vital nutrients. Thus, milk is an excellent example of nano-emulsion.

Liposomal technology is a relatively more complex and new way of encapsulating complex pharmaceutical drugs. Nevertheless, it is a good choice when creating nano-emulsion is not an option. This is because it binds drug molecules in a lipid bilayer.

Key Similarities in Nano-Emulsion and Liposomes:

  • Both are water-soluble or amphipathic carriers resulting in improved bioavailability
  • Both are non-toxic and biodegradable, as they do not use any toxic chemicals in the production process
  • Both technologies are widely used for drug delivery
  • Considerably improved absorption
  • Prolonged CBD’s half-life

Some of the Downsides of Liposomal Technology are:

Liposomes are more complex to produce; thus, products using such technology are more expensive and have other downsides.

  • Larger particles that are >150nm (nano-emulsion particles are generally a few times smaller), and hence relatively poor bioavailability
  • Lesser solubility due to dual lipid layer
  • Shorter half-life
  • Liposomes are quite complex and tend to be unstable, and thus may undergo oxidation or hydrolysis-like reactions
  • Leakage of encapsulated molecules, and thus reduced efficacy
  • High production costs

Essentia Pura Nano-Emulsified Liquid CBD

Before we further discuss why to consider non-emulsion CBD, it is worth understanding that it is not to replace CBD oil but rather to compliment it. CBD oil is still one of the most popular CBD products due to its ease of production, low cost, and high consumer trust level. However, nano-emulsion may help better when someone needs faster-acting products and when higher CBD blood concentration is needed.

There are some good studies comparing CBD oil with nano-emulsions. Those studies show that 50 mg or nano-emulsion may be comparable to 100 mg of CBD oil. However, nano-emulsion would still have some benefits over the regular CBD oil, like almost three times faster absorption and almost 65% bioavailability

It means that if someone uses these products at equal dosages, then the difference would be even greater, and nano-emulsion would not only act faster, achieve health benefits faster, but would have almost thrice greater benefit.

Here are the Reasons Why We Chose Nano-Emulsion:

  • Water-soluble and small particle size.
  • We use special technology to ensure that droplet size remains small and thus ensures high and consistent bioavailability – since droplet size matters, and not all nano-emulsions are produced equally.
  • Faster absorption. 
  • Higher bioavailability when compared to regular CBD oil and even liposomes.
  • More stable molecules mean products continue to have high efficacy during their shelf-life.
  • Bile juices are less likely to influence CBD absorption.
  • Lower first-pass metabolism, as it is vital to know that CBD is metabolized in the liver.

As we have already mentioned, nano-emulsion is not about replacing CBD oil or gummies; it is about complimenting your existing product range with higher efficacy CBD products. 

We believe it is a good idea to have a range of CBD products using regular lipid soluble CBD isolate or broad-spectrum distillate

However, at the same time, it is a good idea to consider water-soluble CBD. It may be especially good for producing certain kinds of products like CBD-infused drinks, making high-potency CBD products, or producing products with more predictable pharmacokinetics that absorb faster, work quickly, and have greater health benefits. For such products, one can use water-soluble nano-emulsified liquid CBD concentrate.

CBD Vaping: Our Comprehensive Guide

The number of young adults vaping is increasing each year. It is relatively safer than tobacco smoking, and thus it has a much wider social acceptability and off-take.

Vaping is also enjoyable and in vogue among young adults. They may use regular CBD-infused fluids or single-use vapes that come in many flavours and different strengths, like Geek bars

Many people find it a good way to reduce stress and enjoy some moments. Thus, many manufacturers have started exploring vaping as a way of drug delivery. For example, CBD vaping has some distinct benefits over CBD oil use or gummies. It means quick action and high bioavailability; for many, it also means ease of use.

CBD Vaping: Is It Safe?

Vaping is quite safe, but not entirely. Initially, producers introduced vaping as a highly safe way to fulfil one’s urge for nicotine and give up smoking. Although this still holds true, as it is much safer than tobacco smoking, unlike tobacco, it does not contain hundreds of harmful chemicals. Even if it contains nicotine, it is not as harmful, and in many cases, it may help give up tobacco smoking.

However, vaping is now a kind of hobby, and vaping liquids do not essentially need to contain nicotine. It means that there are nicotine-free vaping fluids, too. 

Regretfully, as millions of young adults started vaping, reports of severe lung damage also started emerging. It seems that some individuals are sensitive to vaping liquids, and this causes severe lung disease in them. However, such kind of issues is rare. Thus, if you have been vaping for a long time and feel well, chances are slim that it would cause any side effects.

The safety of vaping fluids significantly depends on their content. Thus, some vaping fluids are safer than others. In addition, it appears that some people cannot tolerate the oil-based of vaping juices.

Additionally, studies show that one of the main culprits is vitamin E. Vitamin E is safe when ingested but harmful to the lungs when inhaled. Additionally, some additives like aromas, formaldehyde, and other chemicals that manufacturers use to enhance products’ flavour and stability may also cause side effects.

In short, vaping is quite safe. It is much safer than tobacco smoking. However, it isn’t completely free of side effects. Ultimately, the safety of any vaping liquid depends on its components. Hence, it is vital that producers of CBD vape fluids must know more about the safety of various ingredients added to these fluids.

What Is CBD Vaping? 

Vaping is a pretty simple thing. It is a device with a heating coil. This heating device produces inhalable vapours from the fluid. Thus, CBD vaping means inhaling CBD fluids using vaping devices or pens.

Because vapours quickly reach the lungs on vaping, CBD vaping has excellent bioavailability. In addition, almost all of the inhaled CBD reaches blood circulation almost instantly.

Of course, CBD vaping fluids may contain other chemicals to enhance their flavour. Hence, when vaping, one should also pay attention to what else has been added to any vaping liquid. Though CBD is quite good for health, however, other additives may not be.

What Does Vaping CBD Do?

Vaping CBD would do what cannabidiol or CBD is meant to do. It would provide a quick relaxing effect, improve mood, and have mild pain-reducing action. It would have all the benefits of CBD oil. Moreover, due to its excellent bioavailability, it would have more predictable effects.

Although vaping CBD results in faster action, its effect may not last as long as CBD oil. This is something that one must keep in mind when vaping CBD.

Vaping could be good for those who do not need a very high dose of CBD. Since most vaping fluids contain CBD in lower concentrations when compared to oral forms. However, a higher concentration of CBD in vaping juices is not needed in most cases due to its excellent bioavailability.

Of course, you do not essentially need to vape CBD to manage health conditions. One can also use it to relax, enjoy, and improve mood. It may also help prevent some health issues. 

Does It Get You High?

Let’s answer this most commonly asked question concisely & precisely, “no”.

It is one of the most commonly asked questions or worries. However, it is vital to understand that CBD does not cause high. This is not marijuana. 

Most vaping fluids contain CBD isolate. It means that they contain CBD in its purest form and are free from not only THC, a compound that causes high, but these vaping fluids are also free from other phytocompounds in the cannabis plant. Of course, they might contain other phytocompounds, but only in traces, which have little importance, if any.

Of course, there might be CBD vaping liquids using full-spectrum extract. In such cases, there would be THC in minute amounts. However, this amount is just too small to cause high, though it may contribute to its greater relaxing effects.

What are the Benefits of Vaping CBD?

It is vital to understand that vaping CBD would have all the health benefits characteristic of CBD oil

The main difference here is an immediate effect and relatively short-lasting impact, which makes vaping CBD a better choice in some instances. Additionally, unlike CBD oil, one may vape casually or for fun. Hence, CBD vaping may be better for certain less severe health conditions.

Good for stress relief

It is perhaps the most significant benefit of vaping CBD. It would help relieve stress quickly and help improve mood. Most people love vaping when under stress. Taking timely measures like vaping CBD may also help prevent acute stress from turning into chronic stress. Hence, it may also have some long-term health benefits. 

Antianxiety

Vaping is an excellent way to reduce anxiety, and CBD will have some added benefits for some people. It has a mild relaxing effect, reduces anxiety, and stabilizes mood. 

Pain relief

Of course, do not expect vaping CBD to help overcome severe pains. However, it may have some additive pain-relieving effects when used along with medications. It is especially good for those living with chronic pains.

Reducing the risk of seizures

In recent years, much attention has been given to CBD’s role in preventing seizures. There are even some medications containing CBD for treating resistant cases of seizures. Thus, there is a strong reason to believe that vaping CBD may help prevent epileptic seizures, especially when used along with other medications.

Anti-inflammatory

CBD reduces inflammation and thus lowers the risk of chronic ailments. It means that regular CBD vaping may also help reduce inflammation.

How Much Should I Vape?

It is a complex question due to massive individual differences. For example, some people are more sensitive to CBD than others. Thus, for some few puffs, a couple of times a day would be sufficient, while others would require far more CBD to experience its benefits. Moreover, lots would depend on the CBD’s concentration in any product.

Fortunately, most CBD juices contain low CBD concentration, as they are not for treating some severe ailment but rather for relaxing and having a good time. Thus, most would be safe to use frequently. After all, one does not need to have some illness to vape CBD.

As a Beginner:

Suppose you are getting just getting started with vaping. In that case, it is always better to use CBD vaping juices with a low concentration of CBD, THC-free, something made using CBD isolate, and one that contains a minimum number of ingredients. This will ensure a pleasant experience while minimizing the risk of any side effects.  

Keep in mind that vaping CBD is safe, and side effects occur mainly due to other ingredients and oils, aromas, and so on. Hence, fewer are the ingredients; the safer product is for beginners. Moreover, if you have some reaction to a specific vaping juice, you are more likely to understand the reason or identify an ingredient that your body cannot tolerate. 

And, of course, remember that the maximum daily dose of CBD is 75 mg. However, it is pretty unlikely that anyone can exceed dosage when vaping. 

For example, vaping juices by Koi Hemp come in 250 mg, 500 mg, and 1000 mg strength, and there are 30 ml of juice in each bottle or pack. So, it means that even if you buy 500 mg CBD juice, it would have 16.7 mg/ml. Generally, one ml lasts for about 300 puffs. So, as one can see, exceeding the dosage through vaping is not likely unless you vape continually for hours.

As an Experienced Vaper:

If you are an experienced vaper, then perhaps there is less to worry about as you know that your body can tolerate vaping juices quite well, and there is not much risk. In such cases, you can try vaping juices with higher CBD concentration for stronger relaxing and antianxiety effects. 

Additionally, experienced users can also try full-spectrum CBD vaping juices as they contain terpenes and even THC in permitted amounts (0.3% in the US or 0.2% in the EU). This might provide some additional benefits, like a greater relaxing effect. And such juices may be better for controlling pain and seizures.

Summary:

So, if you like vaping, using CBD-enriched juices could be a good way for you to enjoy all the health benefits of cannabidiol. However, if you do not vape, we recommend avoiding it, as CBD oils or gummies are healthier options. With that said, vaping CBD still has some unique benefits, like faster action and high bioavailability, making it a good choice for overcoming stress and anxiety. If you want to learn more about vape pens, we have written a detailed article about them.

Essentia Pura CO2 Supercritical Extraction

Take a look inside Essentia Pura’s production facility where CO2 supercritical extraction technology is used to produce the highest quality extracts from bioactive ingredients such as medicinal plants, herbs and spices.

 

 

 

CBD vs THC: What’s The Difference?

Humans have used cannabis for thousands of years. In countries like India, people have used cannabis not only for its health benefits but even in religious ceremonies. For example, cannabis-infused drinks are traditionally served at some festivals.

Similarly, Europe has used cannabis for various purposes. It grew hemp widely for its fibre. Its cannabis plant or hemp fibre made sailing possible, as early sails were of textile created using hemp fibre.

Similarly, people in various cultures widely consumed cold-pressed hemp seed oil.

However, things suddenly changed in the late 19th century and early 20th century, when different countries introduced a complete ban on cannabis use. For 80-90 years, cannabis was grown only in small amounts, and its cultivation required a special licence. As a result, people stopped using cannabis for good health. Although, illegal cannabis use continued to flourish.

Researchers now understand that banning all kinds of cannabis products or use was one of the biggest mistakes. Science knows that cannabis has some incredible health benefits. Studies show that most health benefits of the cannabis plant are due to cannabidiol (CBD) and other cannabinoids.

It is now evident that most of the ill effects of cannabis were associated with the use of high tetrahydrocannabinol (THC) cannabis strains. THC is the substance or organic compound in cannabis that causes a high. Thus, if people use cannabis extract responsibly, its benefits outnumber health risks.

CBD vs THC

What’s The Difference Between THC and CBD?

The cannabis plant contains more than 500 known phytocompounds; out of them, more than 100 are cannabinoids. Additionally, it has more than 100 terpenes and many other beneficial phytocompounds.

Studies of various phytocompounds identified in the cannabis plant show that almost all are highly beneficial for health. In addition, they might help manage a range of health conditions.

It is amazing to note that some of the cannabinoids in the plant may even have the opposite effect. However, researchers think they have only discovered the tip of the iceberg, and there is still much to learn about the plant.

THC and CBD are the two most discussed cannabinoids in the cannabis plant. They do share some traits; however, they are pretty different.

Studies show that cannabis causes euphoria or a high due to its content of THC. It is the substance that stimulates the part of the brain known to generate pleasure. In addition, it stimulates the reward pathway and strengthens the memories related to various pleasures. Hence, it not only alters mental alertness but is also highly addictive, too.

CBD is the most abundant cannabinoid in the plant. Fortunately, it is also one of the most studied of all cannabinoids. Most health benefits of cannabis or hemp plant are associated with CBD.

Since CBD is responsible for most health benefits, it is common to isolate this compound for health benefits. That is why people use CBD oil, gummies, tinctures, capsules, topicals, and edibles for health benefits.

What Is THC?

THC or tetrahydrocannabinol is the primary psychoactive compound in the cannabis plant, causing high. It is addictive, and its prolonged use may cause more harm than good.

Here it is vital to understand that THC is also a cannabinoid and may benefit health in minute dosages. Thus, regulations allow CBD products with 0.2% THC.

However, at higher dosages, it would cause more harm than good. At higher dosages, it is more like any other street drug that is addictive, harmful to health, reduces mental alertness, increases the risk of violence, motor accidents, and so on.

What Is CBD?

CBD or cannabidiol is a highly beneficial compound. Most of the health benefits of cannabis or hemp are due to its content of CBD. It is mildly psychoactive, as it helps relax and reduce anxiety and pain sensations. However, it does not alter mental alertness at usual dosages. Thus, it is even safe to dry or operate machinery after using CBD.

Health experts are still discovering its health benefits. For example, in recent years, there has been much focus on its ability to reduce epileptic seizures, reduce spasticity in neurodegenerative disorders, and more.

It is suitable for metabolic health, as it can modulate appetite, reduce inflammation, alter immune responses, and more.

What’s The Difference Between CBD and THC?

The main difference between the two is in their psychoactive properties. CBD has a mild relaxing effect on the brain, even at high dosages. However, THC can cause high or euphoria, completely alter mental alertness, and influence body movements or motor function.

It means that at high dosages, THC is quite different from CBD. Although, in minute dosages, it may have health benefits similar to CBD.

Therefore, in the EU, any CBD products must not contain more than 0.2% THC, whereas, in the US, this upper limit is 0.3%.

Additionally, it is worth understanding that THC ingestion would result in a positive drug test. However, ingesting CBD isolate would not result in a positive drug test.

Does CBD Oil Need THC To Work?

The answer to this question is “Yes” and “No”. THC can influence the working of CBD and can boost its certain health effects. However, CBD also works quite well when used alone and thus does not require THC to work.

THC is one of the cannabinoids; thus, even small amounts of THC in CBD oil may result in the entourage effect. In addition, THC-containing CBD oil may help manage muscle spasticity, insomnia, and low appetite.

However, considering the poor safety profile of THC, it is a good idea to use CBD oil without THC. CBD would work quite well without THC and does not require it at all to work. Thus, CBD alone is sufficient to reduce inflammation, seizures, depression, improve gut health, help with migraine, and much more.

CBD and THC

What Are the Benefits of CBD Oil Without THC?

Although THC may boost certain activities of CBD oil, but it is better without it. It is now proven beyond doubt that THC, on prolonged use, may cause more harm than good. Below are some of the health benefits of CBD without THC:

Better safety profile

CBD oil that is THC-free has a much better safety profile. It will not cause addiction, euphoria, or other severe issues. THC-free CBD oil may also have lower toxicity and would not influence other organs like the liver.

Does not cause high

This is the number one reason for preferring THC-free CBD oil. Cannabis causes high due to its content of THC. CBD isolate does not cause high and has no adverse impact on brain health. This is because it will not influence reward pathways like THC.

Does not increase appetite

It is no secret that marijuana increases appetite. However, CBD helps with weight loss. Therefore, it seems that THC is rather an appetite stimulant.

Would not result in a positive drug test

When testing for drug use, that is, for marijuana use, doctors look for TCH levels in the blood. Thus, even minute amounts of THC in CBD oil may result in a positive blood test. However, CBD oil that is THC-free would not result in a positive blood test.

Easier to get regulatory approval

Finally, THC-free means fewer issues in getting regulatory approval. Most health authorities are wary of THC. They know that prolonged THC use may harm health and is also a substance of abuse. If CBD oil is THC-free, getting regulatory approval would be much easier.

To sum up, cannabis or hemp plant contains many cannabinoids. Among them, CBD and THC are most well researched and have quite different health effects. Therefore, although THC may benefit health in small amounts, using THC-free products is a better option. On the other hand, CBD is still quite potent without THC and is suitable for prolonged use.

If you are looking for THC-free CBD products, we have a range of products. We offer CBD wholesale, white label CBD, private label CBD, and more. We are among the reputed CBD manufacturers in Europe.

What is the Gut-Brain Axis & How Can CBD Affect It?

People often say, “I have a gut feeling, ” when they foresee something happening. For long, it was considered merely a way of expression, with no science behind it. However, now experts think that gut feelings exist. They know that a gut-brain connection exists.

For a long time, doctors and health experts viewed the gut as merely a long pipe-like structure where digestive processes occur. They did not consider any role for the gut beyond digestion. But, in recent years, things have changed due to many discoveries.

Doctors now know that gut can influence the brain profoundly. So, gut and brain health are interconnected in a way that is difficult to imagine. This interconnection between the gut and the brain is called “the gut-brain axis”.

gut brain connection

What is the Gut-Brain Axis?

As already mentioned, studies suggest that the gut has a lot of say in mood and brain health. Some experts are even calling the gut a second brain. Since the gut can influence the working of the brain in many ways, researchers coined the term “the gut-brain axis”.

Here are a few of the crucial discoveries that forced researchers to reconsider the role of the gut in good physical and mental health:

  • The gut contains almost 90% of all microbiota that plays an important role in immunity and produces many vital bioactive compounds, vitamins, and even neuropeptides, thus influencing nearly every body function, including the brain.
  • Researchers now think that alteration in gut microbiota has much to do with mental health issues and even neurodegenerative disorders.
  • The gut has most nerve cells outside the brain. More importantly, there are more afferent fibres than efferent fibres. It means that the gut sends more data toward the brain than receiving. It implies that the gut can alter the brain’s working more profoundly than ever imagined.
  • The gut produces more than 90% serotonin, one of the most important neurotransmitters. Serotonin dysregulation in the brain results in mood disorders and other mental health issues.

As one can see, the above discoveries are amazing. However, there are many other ways in which the gut may influence brain health. For example, the leaky gut syndrome may result in a greater influx of toxins, and chronic inflammation, which may ultimately negatively affect the brain’s health.

How do you fix the Gut-Brain Axis of the brain?

There are many ways of improving the gut-brain axis. However, it is vital to understand that this is a two-way relationship. It means that boosting brain health would help improve gut health, and vice-versa. Therefore, any effort to improve the working of the gut-brain axis must focus on gut health and the brain.

Perhaps it is a good idea to start with the gut. One of the important things to consider is boosting gut microbiota. There are many ways of doing so. One a supplement probiotic and start consuming fermented products like yoghurt or kimchi.

The next approach could be consuming a diet rich in prebiotics. These are dietary components that have a beneficial influence on gut microbiota. Unfortunately, studies show that the western diet is low in dietary fibre, which is one of the leading causes of metabolic disorders and issues related to the gut-brain axis.

Thus, one should consume dietary fibre-rich foods like whole grains, oats, and many fruits and vegetables, while avoiding ultra-processed foods. Foods high in dietary fibre are known to boost brain health due to their influence on the gut-brain axis.

Another way of improving the gut-brain axis is by acting on the brain. It can be done through stress management and reducing anxiety. It is no secret that one of the physical signs of high stress and anxiety is altered gut function.

There could be many ways of calming your brain and gut, like practicing yoga. In addition to all these efforts, one may consider CBD. It acts on both central and peripheral endocannabinoid systems, and thus it can act on the gut and brain. Consequently, CBS is one of the best health supplements for boosting the gut-brain axis.

gut brain axis

Can gut problems affect the brain?

Yes, gut issues can influence brain health in multiple ways. One of the ways in which it can negatively affect brain health is due to malabsorption syndrome and deficiency of micronutrients.

However, malabsorption caused by gut health issues may not be the only way in which gut problems cause brain health issues. For example, studies suggest that those living with chronic gut problems are more likely to be living with anxiety and depression.

Health experts have found many ways in which gut problems may adversely influence brain health. Like it may result in low production of short-chain fatty acids, altered metabolism of specific amino acids, altered vagal nerve activity, and more. Gut problems also cause low-grade inflammation, which may negatively influence brain health.

Can anxiety affect the Gut-Brain connection?

Anxiety is one of the most common mental health issues. Most people would experience mild to moderate anxiety multiple times during the year. However, some may be prone to severe anxiety, causing severe physical signs and symptoms.

Most people know that prolonged and severe anxiety bouts are felt in the gut, as they cause changes in gut motility. However, now researchers know that frequent anxiety episodes or chronic anxiety may lead to severe changes in gut microbiota, and this may have a negative influence on the gut-brain connection.

Anxiety alters gut motility and microbiota, and altered gut microbiota increases the risk of anxiety and depression. Thus, early anxiety management is one of the better ways of breaking this vicious circle. One of the safe and effective ways of doing it may be with the help of CBD oil or other CBD supplements.

Can CBD help the Gut-Brain Connection?

CBD can help the gut-brain connection in multiple ways, as it influences both the working of the brain and gut due to its influence on CB1 and CB2 receptors.

CBD can help stabilize mood, be it anxiety or depression. Thus, it can help normalize the gut-brain connection. It may also have a direct soothing effect on gut health.

CBD can help in other ways, like promoting gut microbiota growth. It may help reduce leaky gut syndrome, modulate immunity, reduce inflammation, and even influence metabolism.

To sum up, CBD is among the few dietary supplements that can influence the working of both the brain and gut; thus, it could be one of the effective ways of improving the gut-brain connection.

If you are interested in exploring more health benefits of CBD, you can get in touch with us. We also offer CBD wholesale, CBD private and white label products. We are one of the premium CBD manufacturers in Europe.

Dropshipping Benefits, Challenges & Getting Started

There are many ways of starting your own CBD business, and dropshipping is one such way. One of the early decisions anyone must make is how and where to source products. One does not essentially need to manufacture CBD products. One can buy CBD wholesale, procure CBD isolate, distillate, and make products.

Even better, one can just buy private label CBD or white label CBD products. These business models require very little understanding of CBD products and only small investments.

For example, white label CBD is quite a simple way of getting started. One just needs to ask the CBD manufacturers about all the products available with them, select the products, and ask manufacturers to label and pack products as per the requirement, and that is it.

However, all the above models have one issue, they require buying some stock. For example, in private label CBD, one may need to buy at least one batch of every CBD product, which is a considerable investment. On the other hand, in the case of white label CBD, one can buy products in smaller amounts, but still, every CBD manufacturer would have a minimum order quantity (MOQ).

Pros and Cons of Dropshipping: An All-In-One Guide

So, what to do, or how to get started if one does not want to maintain any CBD stock?

Well, there is a way out. You can even start a CBD business without buying a single unit of CBD product or investing a penny in stocks. Dropshipping is the simplest way of getting started.

It is the only business model in which a person can have a massive range of products, and yet one would not need to buy any stock. One would not need any place for storage. Not only that, one is not even engaged in product supply. And, yet, consumers receive products as if they were produced and shipped by you.

dropshipping

What Is Dropshipping?

It is the only business model where one can get started with no product stock. The methods are pretty simple. There are dropshipping companies. These may be CBD manufacturers, supplement producers, or even trading companies (often offering thousands of products).

They provide the price of the CBD or other products available for dropshipping. Then, you promote, market, and sell those products like your own products or brands. Once you get the order, you forward it two the dropshipper, and they will supply the product along with your invoice.

Here the customer would make payment to you or at your website. Thus, you will need to pay the dropshipper the basic cost of the product and shipping expenses. What is left after paying the dropshipper is your profit.

This business differs significantly from affiliate marketing, though it may share some of its traits. For example, in affiliate marketing and dropshipping, you have no say in product manufacturing or quality.

However, unlike affiliate marketing, where the customer is redirected to the seller’s website, and you get a commission from every sale, dropshipping differs. In dropshipping, you sell products as if they are your products, and you decide what should be the final price of the product.

In dropshipping, you have greater control over product margins. Moreover, since you are not redirecting customers and selling products like your own products, you can develop customer loyalty over time.

However, unlike private or white labels, maintaining the stocks, storage, and shipping of the products is no hassle. The dropshipper handles everything, and you only pay for whatever sales you make via your platforms.

dropshipping benefits

Top Dropshipping Benefits

Dropshipping is not one of the most popular ways of doing business. In fact, most sellers on eBay and even many on Amazon are working this way. In addition, most sellers or resellers on these platforms are using the services of dropshipping companies. Below are some of the reasons why dropshipping is such a good business model:

  • Low start-up costs: This is the number one reason why anyone would consider dropshipping. No stock maintenance also means zero investment in product stock and storage. In the case of dropshipping, products are lying with the dropshipper, and you have no obligations. Basically, you only buy the product to be supplied after getting payment from the client.
  • Flexibility: This business model provides flexibility in many ways. You can get into the range of businesses, start selling different kinds of CBD products, and more. Since stocks are not with you, there are no pressures of selling them quickly to recover the investments.
  • Massive range of products: Your range of products is only limited by the number of products offered by dropshipper. Thus, most dropshipper would have tens, even hundreds of healthcare products. In addition, a dropshipper may offer not only CBD products but also many other health supplements. To get started, you must decide your margin and list those products on your website. After all, there are no obligations in dropshipping and no investments in product stock.

Other dropshipping benefits

  • No storage of products: In dropshipping, physical products always lie with the dropshipper, and they are also responsible for shipping the products. A good dropshipper would send your invoice along with the product so that customer has an impression as if you dispatched products. All this means there is no need to maintain a warehouse and stocks and requires less staff.
  • Minimal efforts in inventory management: In dropshipping, inventory lies with the dropshipper and not with you. However, you still need to do some inventory management. The number of products with dropshipper may keep changing, and prices may change from time to time. So, yes, you would still require to do some inventory management. However, these are minimal efforts. Moreover, man dropshipper would provide automation software that can readily integrate into most common eCommerce platforms.
  • Easy to scale up your business: Expanding product offerings is a considerable challenge in any business, but not with dropshipping. In the case of dropshipping, one can immediately start offering all the products that are with the dropshipper. Any dropshipper would have tens, hundreds, and even thousands of various products. Thus, one may start with CBD products but readily add other health supplements and even medical devices to the product profile.

 

Some Top Challenges Associated with Dropshipping

Dropshipping sounds too good to be true, and that is right. However, every business model has its downsides, and dropshipping is no exception. Here are a few of the downsides of this business model:

  • Reliance on the third party: One of the biggest issues with dropshipping is that one is over-dependent on the third party. Just imagine that you have spent much effort and money developing your platform. However, one-day dropshipper decides to change their working condition or even close their business.
  • Poor product branding: In dropshipping, you are selling products “as it is”. There is no control over how the products should look, what they must contain, and more. Dropshipper provides ready-to-sell products, but it also means no control over how the product is branded. Quite often, dropshipping products are a kind of product that has huge demand, but they would not offer niche products.
  • No control over product lifecycle: In dropshipping, you may sell the products as if they are your own. But the truth is that those are not your products, and you have no control over the product lifecycle. It means that if the dropshipper decides to change product packing, its formulation, or even discontinue the product, there is nothing you can do about it.

Additional dropshipping challenges

  • High competition: Since dropshipping does not require much investment, many people are using this model. Additionally, dropshipper offers products that are in high demand. However, such products are sold by so many other people. Therefore, you may struggle to differentiate your offering from the competition.
  • Low margins: Almost no product investment also means you will have to be satisfied with low product margins. Products offered by dropshipper are not niche products; thus, there is no scope for massive margins.
  • Low customer loyalty: Since you are offering products that are available on many other platforms, it also means low customer loyalty.
  • Difficulties in providing customer support: You are not supplying the products or maintaining stocks. It means that providing customer support would be challenging if anything goes wrong. Dropshipper may take longer to deliver products, and there might be issues in getting product replacements.

Is Dropshipping Worth It for My Business?

It is a complex question. Every business model is good in one way or another. And every business model has its pros and cons. Some business models may be better for you.

Generally, dropshipping is an excellent business model for getting started quickly with no prior experience selling CBD or other products. It is also a low-risk model. It is also an excellent way to expand the product portfolio quickly.

However, it may not be the perfect way of doing business in the long run. If your sales pick up and your online platform becomes popular, you will realize that you need better products or niche products and provide better customer services. Moreover, if sales pick up, you can make more profit by using models like private label CBD or white label CBD.

If you are unsure how to start with the CBD business, we can help you out. We are a European CBD manufacturer and also provide many other services. Contact us to learn more about dropshipping, private label CBD, white label CBD, and more.

 

What’s The Link Between CBD And Neuroprotection?

In the last few decades, there has been a significant upsurge of interest in various natural neuroprotectants. This rise in interest is due to a considerable increase in neurodegenerative diseases like Alzheimer’s, Parkinson’s, and different neuropsychiatric disorders.

We need to find novel neuroprotective measures to stop the onslaught of neurodegenerative disorders. There are many natural compounds that help prevent neurodegeneration to some extent. For example, it appears that CBD exerts neuroprotective action and can be of significant help in many brain disorders.

One of the reasons it is vital to find natural neuroprotective measures is that doctors still do not fully understand why neurodegenerative diseases are rising. Thus, health experts are failing to explain why early cognitive decline, Alzheimer’s, depression, and various neuropsychiatric conditions are becoming so common.

Experts know that it does not have much to do with genetics, as it has not changed much in the last few decades. However, it does have something to do with changing environments and lifestyle choices. That is why many experts believe that natural remedies could be the best way to counter neurodegenerative disorders.

CBD and neuroprotection

What Is a Neuroprotectant?

CBD appears to be neuroprotective. Therefore, it has many benefits for brain health. However, before looking into CBD, we need to understand what neuroprotectant is.

There is no universally accepted definition of neuroprotectants. Nonetheless, most experts agree that neuroprotectants are substances that help prevent, recover, and regenerate the nervous system, its structure, cells, and function.

Neuroprotectants may be of natural origins or even synthetic drugs. However, medical experts are more interested in natural compounds due to their higher safety.

Additionally, it appears that natural compounds are safer for prolonged use. Studies suggest that neurodegenerative disorders begin several years before their diagnosis. Hence, any natural supplement would work when taken early and used for several months or even years. Therefore, its long-term safety must be established.

How Does a Neuroprotectant Work?

It is a complex question considering that damage to neurons, brain cells, and structures occurs for many reasons. It means that neuroprotectants work in many ways. A good neuroprotectant is one that may help counter neural damage in multiple ways.

For example, in some conditions like Parkinson’s, neuroprotectants work by boosting the production of neurotransmitters like dopamine. In epilepsy, they work by modulating the activity of various neurotransmitters, especially glutamate-mediated neurotransmission.

In other cases, neuroprotectants work by reducing inflammation or modulating immunity. They may also help boost mitochondrial energy production. In addition, some neuroprotectants may help prevent proteinopathies.

Many neuroprotectants work due to their antioxidant capacity. Thus, they might help prevent neural damage due to stress.

In some cases, neuroprotectants may help protect neurons during periods of low oxygen supply. They might achieve this in many ways like reducing inflammation, reducing neuronal energy demand, countering mental stress, and more.

What Are Some Neuroprotective Measures I Can Take Right Now?

There are many ways to protect your brain cells from damage. To prevent brain disorders, it is a good idea to combine multiple non-pharmacological neuroprotective measures.

One should begin by exercising and improving metabolic health. Reducing systemic inflammation through lifestyle changes, reducing exposure to environmental toxins, and using natural supplements may also help.

Here it is vital to understand that one should start taking neuroprotective measures early enough. Once the damage to brain cells has occurred, reversing it is pretty challenging. Moreover, initial damage to brain cells results in a cascade of events that further accelerate the destructive processes.

One must pay particular attention to managing mental stress and anxiety for neuroprotection. Chronic stress is especially harmful to brain health. The human brain is quite good at responding to acute stress. However, it is not made to tackle low-grade and continuous stress. One way to counter this low-grade and constant stress is using natural remedies like CBD oil.

Neuroprotection & CBD: What Are the Neuroprotective Effects of CBD Oil?

The good thing about CBD is its broad spectrum. It may help in a range of brain disorders and help protect brain cells in many ways. Thus, it has many qualities of an excellent neuroprotective agent. But, of course, CBD would work better when used long enough.

  • CBD may exert neuroprotective effects by reducing anxiety and stress and helping with neuropsychiatric disorders.
  • It may help reduce stress and thus the brain’s energy requirement.
  • CBD may exert neuroprotective action by boosting the energy production of neural cells and preventing mitochondrial dysfunction.
  • It may help the brain recover from minor injuries and even concussions and thus reduce the risk of neurodegeneration.
  • It seems that CBD may even help prevent proteinopathies, and thus it can reduce the risk of conditions like Alzheimer’s.
  • Cannabidiol may boost the transmission of certain neurotransmitters and thus boost various brain functions. For example, studies show that CBD may help boost dopaminergic transmission in a nigrostriatal pathway in the brain and thus help prevent or manage Parkinson’s.
  • It acts on various brain centre and thus helps reduce fatigue, spasticity, and inflammation and help people relax better. Therefore, in many cases, CBD may be neuroprotective in more than one way.

CBD as potent neuroprotectant

List Some Ways CBD Acts as a Neuroprotective

CBD acts neuroprotective in multiple ways, and science is still to understand its mechanism of action wholly. Below are some of the ways in which CBD may exert neuroprotective action and thus help boost brain health.

  • CBD may act as an antioxidant and thus help neutralize free radicals; hence it may help prevent neuronal damage.
  • It can modulate immunity and lower inflammation. Altered immune responses are among the most relevant ways CBD acts as a neuroprotectant.
  • It acts on CB1 receptors and thus modulates the working of neurons, and hence it may strengthen neuronal synapses and help counter neurodegeneration.
  • It may modulate the activity of glial cells and thus exert neuroprotective action. Glial cells are the most abundant cells in the brain and play an important role in the brain’s immunity.
  • Alter activity of neural pathways. Cannabinoids may do this in many ways, like altering the concentration of various neurotransmitters, influencing the endocannabinoid system, and more.
  • It can directly impact some neurotransmitters like dopamine and probably serotonin, and thus it may help protect brain cells.
  • It may also help due to its ability to lower mental stress, stabilize mood, and more.
  • CBD may influence neuronal energy production; thus, it is pretty good for those living with ischemic brain injury or even concussion.

Best Neuroprotection Supplements Containing CBD

CBD is good for brain health and has multiple benefits. However, it appears that most CBD products continue to focus on its anti-anxiety effect. Thus, there is still much scope for CBD supplements for brain health.

Although CBD is quite suitable for brain health, combining it with other nutrients or natural extracts may further boost its neuroprotection qualities. Therefore, it is undoubtedly a market segment that must expand in the future.

At present, there are products like CBDistillery that mainly contain CBD isolate. FOCL CBD drops (broad spectrum) or Aspen Green CBD (broad spectrum).

As one can see, that market mainly focuses on anxiety but not on neuroprotection or the long-term benefits of CBD for brain health. Additionally, most products for brain health have CBD isolate, broad spectrum, and even full spectrum.

However, much greater neuroprotection may be achieved by combining multiple natural extracts that are good for brain health. It means there is significant scope for such products in the market.

If you are interested in learning more about CBD and neuroprotection or in introducing CBD products for brain health, you can get in touch with us. We are one of the top-rated CBD manufacturers in Europe. Together we can explore various possibilities. Else, you can also consider products from our range of white-label CBD products.

Artemisia Annua (Sweet Wormwood)

At Essentia Pura, we are not limited to CBD extraction though that is the focus of our business due to massive demand. However, we specialize in obtaining ingredients from various other medicinal herbs like valerian, chamomile, and even Artemisia Annua.

Artemisia Annua is a plant that suddenly jumped to prominence. It is the source of an ingredient called artemisinin which is one of the drugs used to treat malaria and is effective even against resistance cases. It is such an important finding that the person who discovered it was given Nobel Prize in Physiology and Medicine.

However, it is worth understanding that Artemisia is also a good source of other phytochemicals like flavones, flavonoids, phenolic acids, and many more.

Artemisia annua benefits

What is Artemisia Annua?

Artemisia Annua is a plant that is native to the temperate areas of Asia. However, it has not been naturalized in the Americas. It is even grown in parts of Europe, though growing it in Europe requires much expertise.

Artemisia Annua extract has been used in traditional Chinese medicine to treat various ailments, including malaria. Since malaria has become resistant to many commonly available drugs, researchers have been looking for something more potent and newer.

Chinese scientist Tu Youyou was the first to identify that the antimalarial properties of the plant are due to its content of artemisinin. For her discovery, she has received the Nobel Price, as this drug has helped save millions of lives.

Nowadays, Artemisia is also cultivated in Europe, though under specific conditions. Additionally, some  European companies have improved the natural varieties and have created strains that are exceptionally high in artemisinin.

But what is more important is the rising interest in other health benefits of the plant. It would be wrong to think that it is only good for treating malaria. It can also help prevent and manage non-infectious diseases.

Artemisia Annua Benefits

Artemisia is among the neglected herbs, and its benefits mostly remain unknown in the west. It has gained popularity as a herb that is good for managing malaria. However, malaria is not a significant health concern in the West.

Since people in the west are still not using these herbs for various health benefits, there are lots of opportunities. Chinese traditional medicine has used Artemisia for a range of health conditions like reducing inflammation, fighting cancer, boosting vascular health, fighting bacterial and even protozoal infection, treating disorders of the brain, liver, lungs, and many more.

It is vital to understand that its extract is not just about artemisinin. It is more about antioxidants, phenolic acids, flavonoids, and much more.

Its essential oil has a wonderful aroma. In fact, artemisinin is among the minor compounds in the herb. Its essential oil is rich in camphor, beta-caryophyllene, beta-selinene, artemisia ketone, and many more.

artemisia annua usages

Artemisia Annua Uses

As already mentioned, that artemisinin is just one of the minor compounds in the herb. Thus, it is wrong to think about this herb as something good for only treating malaria. In China, people have used this herb to manage a range of medical conditions.

  • Excellent source of antioxidants: Studies show that Artemisia annua is abundant in flavonoids, phenolic acid, and many other antioxidants. Thus, it is quite good for reducing chronic inflammation. It can help reduce the risk of various metabolic disorders.
  • Help fight infections: It is not just good for fighting malaria. It seems that Artemisia extract can help fight a range of infections. Thus, it is quite good for fighting various bacterial and fungal infections. It may be quite good for those living with chronic bacterial or fungal infections, like those in chronic ulcers or those with compromised immunity.
  • Probably effective against covid-19: Of course, it should not be used as a primary covid-19 treatment. However, studies suggest that it may help in multiple ways. Artemisia extract has direct antiviral properties, and thus it is quite likely to suppress the growth of coronavirus. Additionally, it may also help prevent lung damage due to its immune-modulating properties and antioxidant action.
  • Flavonoids and other phytocompounds in the herb reduce cancer risk: There have been many experimental studies suggesting that it could be good for lowering cancer risk in high-risk individuals. It may also work as an add-on treatment in those living with cancer. For example, one of the studies found that it could suppress prostate carcinoma growth when added to prostate cancer treatment.

Is Artemisia Annua Safe?

Artemisia is quite safe. It is not likely to cause any side effects when used as recommended. Here it is vital to understand that there are many reports regarding the toxicity of Artemisia Annua, like severe gastrointestinal issues or even hepatotoxicity. However, these side effects are characteristic of artemisinin which is altogether a different thing. Natural Artemisia Annua extract contains just about 1% of this antimalarial agent. Instead, it contains significant amounts of antioxidants. Thus, it is unwise to compare Artemisia Annua and antimalarial drugs derived from the herb.

Thus, it would be right to say that Artemisia Annua is quite safe for regular use as an antioxidant, for reducing inflammation, and for fighting cancer. However, pregnant and breastfeeding women should avoid Artemisia Annua, as its safety in the population group is not established.

Conclusion

The Discovery of artemisinin, one of the compounds in the plant Artemisia Annua, has been one of the greatest discoveries that helped save millions of lives from malaria. Although this made the plant quite popular, but it also had some negative consequences, as most people started to associate the plant with malaria treatment.

However, in traditional Chinese medicine, the plant has much broader use. Moreover, modern studies confirm that the plant is abundant in numerous potent antioxidants. Thus, Artemisia Annua can help prevent chronic disorders, normalize metabolism, reduce inflammation, and even help fight cancer.

At Essentia Pura, we focus greatly on CBD. However, we are also providing other herbal extracts. Artemisia is still not a commonly used herbal supplement in the western world, despite its many known health effects. Thus, it could be good to add this herb to your product profile, especially if you are into the supplements business.

If you want to learn about all our services or what other herbal extracts we can provide, feel free to contact us.

Ultimate CBD & Hemp Glossary

Whether you are just exploring CBD, an experienced user, or even someone already in the CBD business, you may still find some CBD-related terms daunting. So, no worries, here we have explained all the terms related to CBD use, production, and more. If you still find something missing or you cannot understand, you can always contact us, and we would be glad to clarify things.

Anandamide- It is also called the “bliss molecule.” The human body naturally produces it, and its production may increase under certain circumstances. It acts on the body’s endocannabinoid system. Its higher levels are associated with better mood, cognition, learning, and intellectual and motor function. It especially acts on CB1 receptors. Researchers think that THC and perhaps other cannabinoids can mimic the activity of anandamide, thus causing euphoria.

Bioavailability- Describes how much any compound makes to circulation after ingestion. When ingested, many compounds are neutralised by gastric juices or fail to absorb, or the liver destroys them during the so-called first-pass metabolism. Therefore, higher bioavailability means that a greater amount of the ingested substance can enter the blood circulation and thus help boost health. For example, 50% bioavailability implies that if one ingests 100 mg of a particular substance, only 50 mg of it will make it into circulation.

Cannabigerol (CBG)- Hemp or cannabis plant contains many cannabinoids, and CBG is present in small amounts. It is called a minor non-psychoactive cannabinoid that is a precursor to both CBD and THC. In recent years, there has been increasing interest in minor cannabinoids, as they have different health benefits compared to CBD. For example, studies suggest that CBG may have a higher anti-inflammatory effect on the skin.

Cannabinoids- It is an umbrella term used to describe just any substance that acts on cannabinoid receptors like CB1 and CB2. CBD is just one of the cannabinoids. New studies have identified more than 500 bioactive compounds in hemp, and more than 100 of them are cannabinoids.

Cannabinol (CBN)- One of the cannabinoids present in the cannabis plant. It is mildly psychoactive and is present in traces in the plant. It acts on both CB1 and CB2 receptors. However, there is an increasing interest in it due to its ability to alter some brain activities. Moreover, it appears to be safer and less psychoactive compared to THC.

Cannabis sativa- The cannabis plant has three known species: Cannabis Sativa, cannabis Indica, and cannabis ruderalis. Among these three species, cannabis Sativa is mainly used to produce CBD. It is commonly known as hemp. Europeans have traditionally grown this cannabis species for making industrial products. This variety of cannabis is good because it naturally has low THC content, and thus it is a better fit for producing health supplements.

Carrier oil- CBD manufacturers often buy pure CBD powder like CBD isolate or CBD distillate. However, they must mix CBD with the oil to make CBD or other products. CBD is naturally fat soluble. Carrier oil is just any oil that helps the body absorb CBD. It may be hemp oil, coconut oil, or olive oil, and one can mix multiple oils to create unique products.

CB1 receptors- CB1 receptors are a part of the endocannabinoid system in the human body. Receptors are a kind of switches that are activated by endocannabinoids, cannabinoids like CBD. Once these switches are activated, it changes the body differently. CB1 receptors are mainly present in the brain, though they are also present in small amounts in other body parts. It means that CB1 activation mainly causes changes in brain function, like reduced anxiety or pain sensation.

CB2 receptors- Like CB1, CB2 receptors are yet another kind of switch belonging to the endocannabinoid system and present in various body tissues. Unlike CB1, CB2 receptors are mainly present outside the brain and abundant in the immune tissues. Thus, they help modulate immunity and reduce inflammation.

CBD broad spectrum- Cannabis or hemp plant contains many phytocompounds, not just CBD. Moreover, these compounds may have many additional health benefits. These different compounds are also responsible for the “entourage effect.” Broad spectrum CBD is the extract that retains many other phytocompounds from hemp, except THC. Thus, it is quite safe and yet beneficial for health, as it is THC-free.

CBD extraction- There are many traditional and modern methods of CBD extraction. For example, extracting CBD through oil or alcohol (tincture) is some of the conventional ways. Modern ways of extraction are CO2 supercritical extraction or hydrocarbon extraction. Modern extraction methods like CO2 supercritical extraction help extract pure CBD with very few impurities, and the end product is of high potency.

CBD full spectrum- Full spectrum CBD is quite like a broad spectrum that retains other phytocompounds along with CBD. Thus, it is rich in terpenes, flavonoids, and even vitamins. However, unlike the broad spectrum, it also contains THC in small amounts or permissible amounts. THC in small amounts would not cause euphoria. However, it may result in some added health benefits.

CBD isolate- As the name suggests, it is an isolated form of CBD. It means that CBD isolate is CBD in its purest form. It is almost 99% pure CBD. The distinct benefit of an isolate is that it is better suited for naïve users and is also safe for prolonged use.

CBD/Cannabidiol- Researchers have already identified more than 100 cannabinoids in cannabis or hemp. However, CBD is the most abundant, and other cannabinoids are in small amounts. Thus, CBD is most widely used for health conditions and is also one of the most well-studied cannabinoids.

Certificate of Analysis (COA)- Not all CBD products are made equally well. Quite often, information on the product label may also be misleading. However, a certificate of analysis is the most reliable way of knowing what is in the product. Of course, COA from a reputed third-party lab can only be trusted.

CO2 supercritical extraction is one of the safest and most common ways of CBD extraction from hemp or cannabis plant. CBD manufacturers use CO2 gas cooled and compressed to the supercritical stage in this process. The supercritical stage is the one when CO2 has the properties of both liquids and gases. Supercritical CO2 acts as an excellent solvent and does not leave any toxic residues.

Decarboxylation- It means removing the carboxyl from any molecule. In the case of CBD manufacturing, it helps convert CBDa to CBD and thus helps boost the potency of CBD products.

Delivery methods- CBD products must be delivered to the body and can be done in many ways. The mode of delivery would decide its bioavailability, how fast it acts, and in what conditions it can help. Sublingual, transdermal, topical, and oral are some of the popular delivery methods.

Dietary supplement/Nutraceuticals- Any compound that is used to supplement the diet and may have some health benefits. These are generally of natural origins, but not essentially. For example, many vitamins are produced these days synthetically. Unlike medicine, these are not intended to diagnose or treat medical conditions.

Distillate- CBD distillate is another name for broad-spectrum CBD. It is a CBD product created through the distillation process. It generally contains 70-80% CBD, and the rest is other beneficial phytocompounds like terpenes. The distillate is generally fat soluble; however, water-soluble distillate is also available these days.

Edible CBD- Theoretically, any CBD is edible. However, the term edible CBD is mainly used to describe foods or edible products with added CBD. Thus, CBD-infused chocolate would be categorised as edible CBD.

E-liquid / Vape Juice- As the name suggests, these are CBD-added juices created explicitly for vaping. Vaping has a distinct benefit of immediate effect.

Endocannabinoid system- It is a complex and vast system of receptors and chemicals throughout the body. This system was discovered in the 1990s. It is a system that can alter various body functions like appetite or alertness. Therefore, this system can help regulate different body functions. CBD mainly acts by modulating the endocannabinoid system, which explains its broad spectrum of activities.

Entourage effect- It is a term often used in the CBD world. Unlike synergy, when two substances are combined, it results in much greater health benefits, but the entourage effect is a bit different. When two or more substances are combined, the entourage effect results in entirely new kinds of health effects. Thus, researchers can make products for specific health conditions by combining CBD with various essential oils, terpenes, flavonoids, and minor cannabinoids.

Ethanol extraction is one of the oldest, safest, and cheapest ways of extracting plant extracts. One can soak plant material in ethanol (alcohol) to ensure that its active compounds get dissolved in it. One can also apply heat for higher potency and even distillation to get purer plant extract.

Farm bill- A law introduced in 2018 removes hemp varieties low in THC (below 0.3%) from controlled substances, thus allowing farmers to grow these hemp varieties like any other agricultural product.

FDA- Every nation has a so-called Food and Drug Authority, though its name may differ a bit from country to country. It is a regulatory agency that ensures that medications, dietary supplements, foods, cosmetics, medical devices, and so on meet certain safety and efficacy standards. So, for example, although dietary supplements are not FDA-approved, they still check those products for safety and quality.

Heavy metals- Generally, lead and metals heavier than it is classified as heavy metals. Thus, for example, arsenic is also a heavy metal. Unlike lighter metals like iron or magnesium, heavy metals do not have any role in the human body and are highly toxic, even in small amounts. However, due to air pollution, many natural products may have some quantities of heavy metals. Thus, every natural product must be tested for heavy metals to ensure their safety.

Hemp- A variety or species of cannabis plant that has been specially grown in Europe for making industrial products. It was mainly grown for fibre, making textiles, extracting oil, animal feeds, and more. Leaves, flowers, and stalks of hemp plants are also excellent sources of CBD, as they are naturally low in THC, unlike marijuana plants or other cannabis species like Cannabis Indica.

Hemp seed oil- It is a hemp or cannabis plant seed oil that is rich in omega-6 and omega-3 fatty acids. It is among the healthy vegetable oils. However, it is worth understanding that hemp seed oil is naturally CBD or THC-free. Thus, its sales are not regulated in any nation, and it can be sold and consumed just like any other vegetable oil. It is vital to know that it is naturally CBD-free until or unless CBD has been added to it, as many sellers try to confuse consumers by selling pure hemp seed oil that lacks any health benefits of CBD.

Hydrocarbon CBD extraction- It is another method of CBD extraction on an industrial scale that uses gases like butane or propane. These gases are liquified at high pressure and low temperature; thus, they can dissolve or extract CBD. Although this extraction method is quite good, these gasses are highly flammable and explosive and harm the environment.

Lipid soluble- Anything that is naturally soluble in oils, like CBD.

Marijuana- Cannabis plant flowers, leaves or even stalks from varieties like Cannabis Indica that are naturally high in THC. Thus, unlike CBD, marijuana is mainly used for recreation. However, it may also have health benefits.

Medium-Chain Triglyceride (MCT) Oil- In recent years, MCTs have gained particular attention as they are readily digested. MCTs can bypass the usual way of absorption and can directly enter the lymphatic system. Thus, they can provide quick energy to the body. Not only that, but anything dissolved in MCTs would also enter blood circulation faster.

Novel food- European commission classifies any food item as a Novel that was not consumed in large amounts by Europeans before 15 May 1997. Since Europeans have not traditionally consumed CBD in large amounts, it is also classified as Novel food. Unlike regular foods like wheat or corn, Novel foods can only be sold in the EU after authorisation by the commission.

Organic- Any product of natural origins; thus, it can be readily recycled and does not harm the environment much. For example, paper is generally organic, but plastic is not.

Pesticides- Chemicals that are used by the agriculture sector to kill bugs or insects. However, these food items may retain these chemicals in small amounts, thus causing harm to human health.

Potency- Another way to describe the strength of drugs or food supplements. Highly potency often means a greater dose, though not necessarily.

Private label CBD products- These are products made by a third party but according to the client’s specifications. Nowadays, it is common practice for businesses to get their product manufactured by third parties and instead focus on sales and marketing. Therefore, one can readily buy private-label CBD products, get them branded, and readily introduce them to the market without worrying about manufacturing and regulatory issues.

Psychoactive- Any substance, whether natural or synthetic, that influences the working of the brain, affecting mood, alertness, awareness, thoughts, and more. Thus, alcohol, marijuana, and even caffeine and CBD are psychoactive. However, marijuana and heroin are relatively more psychoactive and therefore are controlled substances.

Solvent- liquid in which solute dissolves to form a solution. Solvents are often used in extracting natural extracts and even making medications. Some of them, like ethanol, are pretty safe, while others might be toxic.

Strain- It simply means variety or species of cannabis. Thus, Indica and Sativa are just different strains of the same plant. However, various strains of the same plant may differ significantly from each other and may have completely different usages.

Sublingual- It is a way of medicine, food, or supplement delivery. When using this route, a substance is held below the tongue for a long time, resulting in its instant absorption, thus reaching blood circulation immediately. This may be a good route for medications or supplements that are not absorbed well via the gastrointestinal tract or are destroyed by gastric juices. However, although this route has the benefit of immediate effect and good bioavailability, it may not be a good route for substances needed by the body in large amounts. Thus, it may be a good route for CBD and vitamins, but not for proteins or carbs.

Terpenes- These are aromatic compounds present in different plants. Plants or even trees use these substances to attract pollinators and defend themselves from different threats. These compounds are quite complex and may have different health effects. Therefore, they are commonly added to CBD products to create products with varying health benefits. Adding terpenes to CBD also results in an entourage effect.

THC/Delta-9 tetrahydrocannabinol is a highly psychoactive compound found in various cannabis strains. It is the main compound in marijuana that causes “high”. It can be addictive and harm health in large amounts. Thus, regulatory bodies only allow traces of THC in CBD products. For example, the European Commission allows only 0.2% of THC in CBD products. Adding high amounts of THC to CBD products is a criminal offence that may result in hefty fines and prolonged imprisonment.

Tincture- Any medicine, herb, or natural compound dissolved in alcohol. It is one of the oldest ways of making medications and health supplements. In olden times, people would collect herbs and soak them in alcohol for weeks or months. Soaking herbs in alcohol for long dissolves many of their active compounds, thus creating a kind of natural medication or tincture.

Topical- Any medication or substance that is applied to the skin. Generally, such compounds have a local effect, like helping reduce skin inflammation.

Transdermal patches- It is one of the modern ways of drug delivery. Manufacturers may add medications, different compounds, hormones, or even CBD to the transdermal patches. These patches can adhere to the skin; from there, they keep supplying medicines in small amounts over a long period. For example, a testosterone transdermal patch may consistently supply a low dose of hormone for 24 hours. In this delivery route, medication or other substances are slowly absorbed via the skin.

Vaporiser- Any equipment or device that creates vapours of fluids or solid substances. For example, some asthma medications are taken this way. Similarly, vaping devices are also vaporisers, and they can create vapours of vaping juices. It is one of the fastest ways to deliver drugs, as active ingredients instantly reach the bloodstream through the lungs. It may also be a good delivery method for medications acting on the respiratory tract, like bronchodilators.

Water soluble- Any substance that is soluble in water. Quite often, a water-soluble substance is poorly soluble in fats and vice versa. Additionally, it is worth noting that the human body absorbs and processes water-soluble substances differently than fat-soluble substances.

White-label CBD products- It is the easiest way of getting started with the CBD business. These products are ready with the manufacturer and need to be labelled as per the client’s requirement (thus the term white label). Quite often, a good CBD producer would have a range of white label CBD products. However, these products were not made as per the client’s requirements.