Is CBD Legal in Georgia?

Georgia is a beautiful, geographically and culturally diverse nation located in the Caucasian mountains and has access to the black sea. Its location at the edges of Europe and Asia makes it a unique country. Technically it is in Asia. However, culturally most people of the nation associate themselves with Europe.

Like the countries that border large continents, it has a unique culture that mixes different values. Yet, it is a modern, forward-looking, and economically thriving nation.

It has been a part of the Soviet Union and thus a communist country for a long. However, unlike some other ex-soviet republics, it has made excellent progress towards democratization and liberalization. Therefore, no surprise that the legal structure in the country is quite European. After all, the country aspires to join the EU union one day.

It has definitely made much progress in liberalizing the economy and reducing the red tape. It means a clear legal structure, fewer loopholes, no unnecessary regulations, ease of doing business, etc.

Therefore, no surprise that it is among the first ex-soviet nations that began talking about the health benefits of CBD.

It is also among the first ex-soviet nations to simply the process of starting health supplements and even the pharmaceutical business.

Georgia and CBD

Is CBD Legal in Georgia?

Georgia is a pretty friendly and hospitable nation that is counting big on its tourist industry. Thus, it has to improve regulations regarding CBD and cannabis in general.

Traditionally, Georgians also had a different attitude towards mind-altering substances compared to other countries in the region. It is a country that prides itself as a nation that created the wine. It has an ancient winemaking culture – older than many of the well-known global wine producers.

These attitudes perhaps helped the nation to understand the CBD better. As a result, it became the first ex-soviet nation to legalize CBD. But not only that, it is the first ex-soviet nation to legalize the recreational use of marijuana.

So, yes, CBD is entirely legal in Georgia. Not only that, even possession and use of recreational marijuana are legal in the nation. When it comes to the use of recreational marijuana, the law only says that it should be used at home and not in public places like cafes, streets, and so on.

Cannabis was legalized in Georgia by the ruling of the Constitutional Court of Georgia on 30 July 2018. It made it the first ex-communist country in the world to legalize cannabis. Not only that, it is among the hand full of nations in the old world legalizing both CBD and recreational cannabis.

A Brief History of Georgia Cannabis Laws

Like all ex-communist nations, things have not been as rosy in the nation. However, unlike other ex-communist countries, Georgia has been quite good at carrying out constitutional reforms and liberalizing the economy. As a result, it is among the most liberal nation in the ex-soviet territory. Thus, it was not surprising that it became the first nation to legalize CBD.

It is impressive to see how Georgia could legalize CBD in quite a short time. It may be explained on the basis that it also became the first ex-soviet nation to deregulate the health supplement industry.

For example, in most of the ex-soviet republics, one still has to go through a tedious process of registration of health supplements in the ministry of health. However, in Georgia, things differ, and one only has to prove the product’s safety.

When it comes to CBD and its legalization, it all started in 2015 when many segments of the society and political elite started demanding the legalization or decriminalization of the CBD and even marijuana possession. One of the political parties, the Girchi Party, played a significant role in CBD legalization.

After multiple efforts, the Constitution Court of the nation finally legalized both CBD and recreational marijuana in 2018.

Georgia and CBD law

How to Start a CBD Business in Georgia

Georgia is quite liberal, and starting a CBD business in the nation might not pose many challenges. But nevertheless, it would depend much on the origins of the product.

It is vital to understand that Georgia is not an EU member. But on the other hand, it accepts many EU norms and regulations. It means that in Georgia, CBD is not a novel food, and Georgian authorities would see it as just any other health supplement.

As per Georgian law, if any food product or health supplement is legally produced in the EU, such a product is also good for sales in the nation. Thus, one would need minimum documents. One would need to prove that the product is of EU origin. Additionally, one may need to provide a certificate of analysis to prove the product’s safety.

In most cases, if a product is produced in the EU zone, these documents would be readily available. It means that there are almost no hurdles to starting a CBD business.

However, when it comes to manufacturers located outside the EU, like in other Asian nations, things may differ. For them, also, things are pretty simple. However, they would be better off getting a local certificate of analysis before importing the product. This will prove that CBD product is safe for human use, and it does not contain THC above the universally accepted norm of legal CBD products, which is not more than 0.3%.

Can I Take CBD Oil to Georgia?

Legally the answer is yes, and you can take CBD oil to Georgia if you can prove that it is for personal use. It generally means a single small bottle of CBD oil. However, in practice, things might differ. There are always fears that a person may bring high THC products in the name of CBD oil. It means that there might be some trouble with customs in some cases.

To conclude, Georgia is the first ex-soviet nation to legalize the CBD and even recreational use of marijuana. It means that starting a CBD business in Georgia is relatively simple. Likewise, if the product is produced in an EU nation, it is relatively easy to import and sell. However, if CBD is made outside the EU, some additional documents might be needed to prove the quality and safety of the product.

Contact us if you want to start a CBD business in Georgia, our team of experts can suggest the best way of getting started.

Minor Cannabinoids: Everything You Should Know

Humans have used cannabis for thousands of years for recreation to industrial use. Besides, they also knew that its extract could help in a range of health conditions.

However, the use of marijuana was suddenly outlawed in most parts of the world by mid-20-century. Regretfully, most countries even banned the cultivation of low THC cultivars. Fortunately, researchers started realizing that not all cannabis products harm health. And some are even quite beneficial.

Despite the ban on recreational use of marijuana in the early to mid of the last century, its medicinal use was allowed. As a result, researchers continued to explore its chemical properties. As a result, they understood that this plant has many unique phytocompounds and more than 100 cannabinoids.

However, despite discovering so many cannabinoids, it would be correct to say that science has been slow to explore the health benefits of various cannabinoids. The popularity of cannabidiol (CBD) has not helped in this direction. In fact, the popularity of CBD had even prevented the study of other cannabinoids.

CBD is undoubtedly among the most abundant cannabinoid, and many of its health benefits are known to science. But now, scientists realize that some unique health effects of cannabis plants are due to the entourage effect that occurs in the presence of other cannabinoids and terpenes in the plant.

minor cannabinoids and health benefits

What Are Minor Cannabinoids?

CBD, THC, and even CBG are in abundance in many cultivars of the cannabis plant, and thus they are called major cannabinoids.

However, there are almost close to 100 known cannabinoids that are very poorly known to science. Nonetheless, things are not that bad, as science now knows the health benefits of tens of these less common cannabinoids.

These cannabinoids are present only in small amounts in the cannabis plant, and thus science calls them minor cannabinoids. However, in the specific cultivars of the cannabis plant, these compounds are more abundant.

There are many ways of getting these minor cannabinoids, like growing cultivars of the cannabis plant in which they are more abundant or using the knowledge of chemistry to change major cannabinoids to minor ones.

There are even some successful attempts at synthesizing these minor compounds. Thus, they are quite likely to become popular in the future, finding broader use as health supplements.

What Are the Types of Cannabinoids?

There are many types of cannabinoids like neutral cannabinoids, cannabinoid acids, varinic cannabinoids, and many other minor cannabinoids.

Though they might belong to different groups; however, the difference is generally minor. Quite often, shared traits are more than differences. It is because they all have a similar beginning. However, even these minor differences in a chemical structure may sometimes result in a considerable change in health benefits.

minor cannabinoid

What Are the Effects of Minor Cannabinoids?

Although there are hundreds of cannabinoids, there we look at some of the more popular ones. About ten of the minor cannabinoids are more or less well studied by science. Rest are still waiting for science to discover their health effects.

Cannabinol

Cannabinol, or CBN, is one of the earliest known cannabinoids that science discovered way back in 1896. It is a result of the degradation of THC under the influence of UV rays. It means that it is more commonly present in plants abundant in THC.

This minor cannabinoid is quite a potent analgesic and also has anti-inflammatory properties. In addition, it is suitable for controlling muscle aches. Science has found it suitable for those living with fibromyalgia in recent years.

Additionally, it is suitable for modulating immunity, reducing the risk of various allergies. Finally, studies show that it is also ideal for controlling glaucoma.

When it comes to metabolic effects, it seems to stimulate appetite.

It is suitable for reducing anxiety, promoting relaxation, and improving sleep quality.

Cannabichromene

Cannabichromene or CBC is in abundance in some cannabis cultivars. It appears to have a greater affinity for CB2 receptors than CB1, which means that it affects peripheral organs more than the brain.

Some researchers have studied it for its anti-inflammatory action. In animal studies, it seems to be as good as some of the commonly used medications but without their side effects.

Science has also explored its ability to reduce neurodegeneration, which may be associated with its anti-inflammatory action. Additionally, it seems to stimulate neural stem progenitor cells and thus have a beneficial effect. It may also help in neurodegeneration by modulating the brain’s immune cells and astrocytes. It is quite likely to be good for preventing and managing Alzheimer’s.

Cannabigerol

Cannabigerol or CBG is a precursor of THC and CBD, meaning that these well-known major cannabinoids are formed in the plant through the conversion of CBG. However, as the plant matures, CBG levels decrease. It also means that it has the properties of influencing both the CB1 and CB2 receptors.

It appears to be especially good for reducing inflammation. Researchers have paid particular attention to its role in managing inflammatory bowel disease (IBD), especially Crohn’s disease. It may help prevent its exacerbation and help maintain its prolonged remission. It appears to help in multiple ways, from reducing inflammation and boosting NO production to helping fight oxidative stress.

Since it is so good for reducing inflammation, it is also beneficial for brain health and may have a role in neurodegenerative disorders. Additionally, it also demonstrated anti-cancer activity in many experimental studies. It may suppress the growth of cancer cells and reduce the risk of metastasis.

Cannabidioloic Acid

Cannabidioloic Acid, or CBDA, has a low affinity for CB1 or CB2 receptors, but it may act on other pathways, including the serotoninergic pathway. Due to its impact on various inflammatory enzymes, it is especially good for reducing pain and inflammation. CBDA is especially good for preventing hyperalgesia or increased pain sensation found in conditions like fibromyalgia.

CBDA also has a potent nausea-reducing effect, which is much stronger than CBD. In addition, it appears to suppress acute nausea quite well and thus can be part of anti-cancer treatment.

Further, some experts suggest that it may be more effective than CBD in controlling seizures. Thus, it is better for those living with conditions like resistant epilepsy.

Cannabigerolic Acid

CBGA is the father of all major cannabinoids that is THC and CBD. It is especially good for those living with metabolic disorders and it may help prevent cardiovascular issues. Studies show it to be good for reducing insulin resistance. In addition, some studies suggest that it is good for relieving nausea and preventing vomiting.

Researchers are also exploring its role in cancer prevention. For example, it may help prevent certain types of cancers like colon cancer and even leukemia.

Tetrahydrocannabinolic Acid

Tetrahydrocannabinolic Acid, or THCA, is the father of THC. However, it is non-psychotic and thus safe to use for health benefits. In recent years, science has explored its anti-inflammatory action. It appears to be quite good for reducing inflammation caused by various disorders. It is not only good for local inflammation but also systemic inflammation. Thus, for example, one study shows that it may have a role in managing inflammatory conditions like COPD.

Science is also exploring many other amazing effects of this minor cannabinoid-like anti-inflammatory activity and its role in preventing dementia. It may also help prevent seizures and help reduce rigidity in Parkinson’s.

Cannabidivarin

Cannabidivarin or CBDV is suitable for managing seizures due to its impact on various brain centers. As a result, in recent years, it has gained significant attention for treating epilepsy, and many pharmaceutical companies are testing it to manage the condition. At least, early results are highly encouraging, and CBDV-based medications to treat epilepsy may likely get an FDA nod soon.

It is also suitable for other brain disorders like autism spectrum disorders. In addition, it may have a role in managing multiple sclerosis and even in rare conditions like Duchenne muscular dystrophy (DMD).

Tetrahydrocannabivarin

THCV is good for reducing inflammation, though at present most of the evidence comes from studies in mice. It also showed some promise in managing epilepsy. Additionally, it can help lower blood glucose levels. Some studies have also explored its role in various skin disorders.

One interesting fact to note about THCV is that studies seem to suggest that it is a negative modulator of the endocannabinoid system, which is just the opposite of what major cannabinoids like THC or CBD do. So, it means that it may have a role in managing substance abuse and reducing the side effects of marijuana.

This is undoubtedly not a complete list of all the minor cannabinoids. This discussion only demonstrates how various cannabinoids differ from each other. Exploring the role of each cannabinoid may help create unique health supplements and even medications. In many cases, these remarkable compounds may even help treat some rare disorders like muscular dystrophies or multiple sclerosis.

There are many other minor cannabinoids that science is studying, like Cannabitriol, Cannabicitran, delta-8 THC, and more. What is interesting is how diverse these cannabinoids are in their health effects. Some may boost the function of CBD or THC, others modulate their health effects, while some may even act as antagonists of these well-known major cannabinoids.

To conclude, science has paid much attention to CBD and even THC in the last few decades. However, studies indicate that many minor cannabinoids also possess amazing health effects. Thus, it is now time for science to start exploring these minor cannabinoids and studying how various cannabinoids interact with each other. As we explore these minor constituents of cannabis, we are pretty likely to find some compounds with unique health effects.

If you are interested in learning how minor cannabinoids can help you create unique products, contact us, we would be happy to help you out.

What is Cannabicitran (CBT)?

Researchers have long observed the phenomenon that fresh herbs or whole herbal extract work better than some of the isolated compounds from those herbs. It is because, in herbs, hundreds or perhaps thousands of organic compounds work in synergy with each other.

Since there are so many active compounds in every herb, identifying all of them is almost impossible. Even identifying most of the vital compounds and understanding their mode of the action takes decades, if not centuries.

All this means that we have just discovered the tip of the iceberg. There is still a lot to be understood about the cannabis plant. Each year, the number of active compounds identified in the cannabis plant increases. Researchers have identified more than 500 organic compounds and 100 cannabinoids in the cannabis plant.

What has puzzled researchers is that these hundreds of compounds may sometime enhance the action of each other. Other times they may act just in an opposite way. Therefore, to create a perfect symphony, these compounds must be combined in a specific way, a secret known to nature. But unfortunately, recreating this symphony is still out of the realm of modern science.

cannabicitran uses and benefits

Understanding the “entourage effect.”

In pharmacology, if two drugs boost the action of each other and one plus one becomes more than two, it is called synergy. However, the entourage effect is even more complex and powerful.

When you use certain compounds in an isolated form, they may not work at all. However, when you combine them with one or more than one compound, a new kind of potent health effect emerges. CBD experts call it “the entourage effect.” It is not just about boosting the effect of each other, but many times creating an absolutely new kind of effect.

Thus, cannabidiol (CBD) is good. However, if you combine it with other cannabinoids, CBD may start working much better in many health conditions. But that is not all, and it may even begin helping in health conditions in which CBD does not work when used alone. That is why understanding the entourage effect is so important.

It is vital to understand that it is not essential to combine multiple cannabinoids for the entourage effect. One may even combine CBD with other organic compounds. Thus, for example, adding terpenes to CBD products may help provide designer products, products that are especially good for managing certain health conditions.

For example, new studies show that CBD may work much better in managing mood disorders or anxiety issues when combined with terpenes.

What is Cannabicitran (CBT)?

We know that more than a hundred cannabinoids exist, but they remain relatively unexplored. This is despite the fact that science discovered many of these compounds more than half a century back.

CBD is good, but it is vital to explore the less common cannabinoids in the cannabis plant to create safer and more potent remedies for various health conditions.

Many of these cannabinoids are present in traces in the cannabinoid plant. Thus, extracting them on an industrial scale could be a challenge. But then, with an improved understanding of the cannabis plant, science may find ways to convert more common cannabinoids into less prevalent cannabinoids.

As far as Cannabicitran is concerned, it was isolated from the cannabis plant way back in 1974. Researchers have since then known its chemical structure. They even know that it is structurally quite close to some of the synthetic chemicals.

Interestingly enough, Cannabicitran is also present in many other plants and herbs. For example, one of the studies has identified it even in the flowering plant  Rhododendron anthopogonoides.

It is regretful that Cannabicitran remains a poorly studied cannabinoid despite all the interest. In fact, a search on PubMed, the medical research database of the National Library of Medicine, one of the most extensive databases of its kind dedicated to medical research, returned less than 5 results on searching for Cannabicitran.  That is really low compared to cannabidiol (CBD), with almost 5000 published research articles.

Cannabicitran shares many properties with CBD and is a non-psychotic cannabinoid. It means that quite like CBD, it does not cause a high and it is pretty safe and non-addictive. Additionally, it has a relaxing effect and may help overcome pain.

It appears to be especially good for managing glaucoma. It may help lower the intraocular pressure. This is quite interesting, as very few cannabinoids are so good for glaucoma. At present, only one study has shown its benefit in glaucoma, and there is definitely a need for more clinical studies to confirm its usefulness in the condition

CBT vs. CBD: What’s The Difference?

Cannabicitran (CBT) appears to share many traits with cannabidiol (CBD). Both the cannabinoids are non-psychotic. They have relaxing and pain-reducing effects. In addition, both are quite safe for humans and are non-addictive.

However, unlike CBD, it appears that CBT is better for reducing intraocular pressure and thus more beneficial for managing glaucoma. In addition, it is not clear if it can also help with other eyesight problems.

However, unlike CBD, CBT is much less popular and poorly studied by science. It means that it may have many other health benefits, and future studies will shed more light on them.

cannabicitran uses and benefits

Cannabicitran Benefits to The Human Body

CBT appears to be similar to CBD but with some differences. Thus, it is suitable for anxiety and stabilizing mood and may also help with pain and other health issues.

Further, studies show that it is especially good for eye health and may help prevent or even manage glaucoma. However, in some individuals, it is pretty challenging to treat and may even cause worsening of vision.

Cannabicitran Effects: What’s It Used For?

At present, science has a limited understanding of CBT. But they know that it is good to mix it with CBD. In such cases, it appears to increase the health benefits of CBD due to the entourage effect. However, it is rare to use CBT in its isolated form. Additionally, studies show that it may be particularly good to use along with CBD for those living with glaucoma.

Further, studies show that CBT is good when combined with CBD, especially in vape oils. Some studies suggest that it can help prevent the crystallization of CBD and thus improve the shelf life and effectiveness of CBD vape oil.

To conclude, Cannabicitran (CBT) is one of the cannabinoids researchers discovered way back in 1974. Nonetheless, it remains a relatively poorly known cannabinoid. Therefore, it is good to combine it with CBD for the entourage effect. Additionally, it is good for those living with glaucoma. CBT can also help prevent the crystallization of CBD in vape oils and thus prolong its shelf life.

If you want to know more about creating unique CBD products and learn more about uncommon cannabinoids, get in touch with us.

 

Essentia Pura Attends the Natural & Organic Products Europe in London

Finally, after 2 long years spent mostly on online calls and meetings due to Covid-19, we were finally able to meet with our partners in person and make new connections on the 3rd and 4th of April at the Natural and Organic Products Show at the Exhibition Centre London.

We would like to thank Spirit Slovenija since this operation was selected for co-financing on the Public tender for co-financing individual participation of companies at international trade fairs abroad in the years 2019-2022.

The investment is co-financed by the Republic of Slovenia and the European Union under the European Regional Development.

We were happy to see the visitors finding interest in our products and services. We have gained lots of attention, especially from shops specializing in natural products who were looking for white-label solutions. Our recently developed natural CBD skincare products got the most interest.

Visitors were greeted by Nejc, Manca and Oliver who presented our company, our products and the services we offer.

Overall they attracted an attendance of around 7.000 visitors who came to meet 800 exhibiting companies, covering the fastest growing sectors in retail, including organic, vegan, and free-from food, drink, supplements, personal care, and natural beauty. With buyers representing the full retail spectrum, from major multiples, to online, convenience, premium stores and the important independent health store sector. The event is also gaining an increasingly international following, with over 1,000 major buyers representing some of the most important retailers from 73 countries.

CBGA (Cannabigerolic Acid) What It Is, Uses & Benefits

The cannabis plant is not just about cannabidiol (CBD). CBD is just one of the most abundant cannabinoids. Even cannabis experts of 20-century knew that there are many other cannabinoids. And researchers could discover many of them in the mid of the last century.

Any plant contains thousands of organic compounds that work in sync with each other, providing nutrients and health benefits. But, since plants are so complex, identifying the beneficial compounds is challenging even for modern science.

The list of identified organic compounds mostly unique to the cannabis plant is expanding fast. New studies could identify more than 500 beneficial compounds and above 100 cannabinoids in the plant.

Understanding various cannabinoids is vital, considering that they have different biological effects. However, what has amazed researchers those various cannabinoids not only have different health effects, but they can often have just an opposing action on the human body.

CBGA molecular structure

What is CBGA?

CBGA is one of the non-psychotic cannabinoids in the cannabis plant. Researchers have identified more than 100 cannabinoids in cannabis or hemp plants, but there is something unique about CBGA.

CBGA is unique in the way that it is a precursor to all other cannabinoids. It means that it gets converted to all other cannabinoids in the plant, including CBD and THC. It also means that it is regularly produced in the plant in small amounts for later transformation into other compounds.

CBDA and CBGA: What’s the Difference?

To understand the difference in a simple term, CBGA is the grandfather of all cannabinoids, and CBDA is the father of CBD.

In the hemp plant, enzymatic activity converts CBGA to CBDA (Cannabidiolic acid), CBCA (cannabichromenic acid), and THCA (tetrahydrocannabinolic acid). Therefore, it means that CBD, CBC, and THC are the outcome of enzymatic conversion of CBDA, CBCA, and THCA, in hemp or cannabis plant.

Thus, various enzymes convert CBGA to different cannabinoids, including CBDA. Although CBDA is related to CBGA, it is chemically different, and it also means different health benefits.

It is worth understanding that science is still exploring the health benefits of non-CBD cannabinoids. Studies show that even a tiny change in the chemical structure of any cannabinoid may significantly alter its role in the human body.

However, the complex is to understand the interaction of various cannabinoids to demystify the “entourage effect.” Researchers know that taking multiple cannabinoids is more beneficial. But they do not understand how different cannabinoids potentiate the action of each other.

CBGA Effects: How Does It Feel?

CBGA is a non-psychotic. It means that a person using it would not get high. However, it does not mean that it would not have any impact on the brain. It only means that it would have mild action on the brain that would be pleasant, relaxing, and perhaps pain relieving.

It may also help lower stress levels and anxiety, reduce nausea, and help a person feel fresh. So, it would provide relief due to its impact on CB1 receptors in the brain and its effect on CB2 receptors in other body parts.

CBGA benefits

CBGA Benefits for The Human Body

Although CBGA is less studied by science than CBD, nevertheless, there are many studies indicating that it may help in various ways. In addition, some of the experience regarding its health benefits come from the use of broad-spectrum CBD. Thus, it is good to use alone or in combination with CBD.

Diabetes & Heart health

It is no secret that there is a strong association between diabetes and vascular diseases. Studies show that CBGA can inhibit an enzyme called aldose reductase, and thus help reduce glucose levels in the body. It also has a positive impact on lipid profile.

CBGA is not very harsh, and most of its actions are mild. Thus, do not expect to lower glucose immediately with CBGA. However, its prolonged and continuous use would help gain better control over blood glucose and improve lipid profile. Moreover, it has an excellent safety profile.

Further, studies show that it may help with diabetes or metabolic disorders due to its ability to modulate receptors called PPAR. These receptors play an important role in cellular metabolism, and their dysfunction is associated with the development of insulin resistance and diabetes.

It May help control epilepsy

The role of cannabinoids in controlling epilepsy has become a subject of high interest in recent years. It happened due to the approval of a CBD-based drug by the US FDA and EMA. Now researchers know that they are treading the right path. They understand that many benefits of hemp extracts are due to lesser-known cannabinoids.

Like other cannabinoids, researchers are testing CBGA for its anticonvulsant properties, and the initial results are highly encouraging. Early studies show that CBGA is undoubtedly one of the cannabinoids good for reducing convulsions in epilepsy. There is strong evidence from earlier animal studies that it works.

Other health effects

Despite its discovery more than half a century back, there is still limited research into its health benefits. It is because most cannabis research stopped for most of the second half of the 20th century. However, new studies indicate that it is suitable for reducing inflammation, pain, and stress and has many other benefits.

From CBGA to CBG: What’s The Process?

As CBGA is the father of all cannabinoids, it is possible to convert it into other cannabinoids like cannabigerol (CBG). In some cases, this conversion may require the use of specific enzymes; in other instances, just an application of heat.

CBGA is pretty simple to convert to CBG through heat application which results in the decarboxylation of CBGA and formation of CBG. CBG is no longer an acid. CBG is of particular interest due to its opposing action to THC.

Thus, CBG antagonizes CB1 receptors in the brain, unlike THC. This opposing action means that it may play a role in managing marijuana addiction and other substance abuse disorders. Additionally, it also appears to affect adrenergic receptors and serotonergic receptors and thus help prevent mood disorders and other brain issues. It is also suitable for reducing inflammation.

To conclude, science has developed a sufficient understanding of CBD, and now is the right time to start exploring other cannabinoids in cannabis or hemp plant. Further, there is a need to understand how they interact with CBD and explore their health benefits.

If you are interested in exploring the power of CBD, understand what products are right for you? Just ping us.

 

CBDV (Cannabidivarin) What Is It, Uses & Benefits

Thousands of articles are written each year about cannabidiol, or CBD. CBD is revolutionary in many ways. It has become the most popular cannabinoid compound in history. It has also helped revolutionize the industry, and help make THC-free cannabis extract legal to produce, sell, possess, and use.

But there is some downside also to such immense popularity of CBD. Its popularity means that most people and even researchers seem to overlook the fact that the cannabis plant is not just about CBD. It has many more beneficial compounds that need to be discovered.

Studies show that cannabis plant extract may have as many as 400 chemical compounds with different health effects. Moreover, 100 plus of these compounds is cannabinoid compounds.

CBDA (Cannabidiolic Acid): Everything You Should Know

What is interesting about various cannabinoid compounds is that they have very different biological effects despite a similar structure. It means that in some cases, seemingly similar cannabinoid compounds may have completely opposed action. Thus, some may suppress appetite, and others stimulate, some may suppress immunity, others boost, and so on.

It is clear that this amazing plant has much more to offer. Using pure CBD is good, safe, and time-tested. However, it is time to explore other cannabinoids in the plant. It is vital to understand their health effects and start using them alone or along with CBD.

It is entirely possible that tweaking the content of various cannabinoids in a supplement may help produce products with unique health benefits.

Researchers have already started exploring various cannabinoids. And one such cannabinoid is Cannabidiolic acid, or CBDA. It is entirely possible that it may gain significant popularity in the near future due to its unique health effects.

What Is CBDV?

Cannabidivarin or cannabidivarol is one of the non-psychoactive cannabinoids present in the cannabis plant. It is one of the more than 60 known cannabinoids. It is present in very small amounts in most cannabis species or hemp plants.

Although it is not known well in the cannabis world, it was identified in the plant way back in 1969. It is especially high in certain cannabis varieties native to Asia, like cannabis Indica.

CBDV molecular structure

CBD vs. CBDV: What’s The Difference?

CBDV is only slightly different from CBD in chemical structures. However, this is enough to provide it with some unique properties. Nonetheless, it appears to share many of the benefits of CBD, too.

Thus, CBDV is good for reducing inflammation. However, compared to CBD, studies show that it may have a more significant effect on endocannabinoids and other receptors in the brain. Thus, it appears to be especially good for brain disorders, pain, and seizures.

Additionally, when compared to CBD, it may be better for mood disorders, overcoming nausea. It appears to be also suitable for digestive health.

Thus, it seems that it is quite similar to CBD but has more potent action on some brain receptors.

CBDV Benefits for The Human Body

Some the pharma companies like GW pharmaceuticals already have CBD-based approved drugs for the treatment of resistant epilepsy. And it appears that it is also highly interested in exploring the role of CBDV in controlling seizures.

Some of the early studies in both animals and pilot studies in humans show that it is quite good in reducing the frequency of seizures in some kinds of epilepsies. It seems to act both on CB1 and CB2 receptors. Additionally, researchers are also exploring its role in autism spectrum disorders.

There is really strong interest in this molecule in managing seizures, brain disorders, mood issues, and inflammation. Moreover, it is now readily isolated from the cannabis plant, and its chemical structure is understood well.

In recent years, another company called Jazz Pharmaceuticals has also started clinical trials for CBDV in Autism Spectrum Disorders and another study in a rare kind of resistant epilepsy.

When large pharmaceutical companies start exploring some molecules, it generally means that they have a high level of confidence in the efficacy of the molecule. Here it is essential to understand that Jazz Pharmaceuticals or GW pharmaceuticals are carrying out clinical studies to get the US FDA nod for the use of CBDV as a medical drug.

However, such clinical studies are not needed for using CBDV as a health supplement. Greater CBDV might likely contribute to the higher effectiveness of broad-spectrum CBD products in various brain disorders.

Further, exploring its use in controlling pain, nausea, swelling, nerve pains, mood disorders, and maybe even overcoming substance abuse disorders is good.

Cannabidivarin Effects: What’s It Used For?

At present, very few supplements are using CBDV, and thus the market is nascent. However, it means that there are a lot of opportunities for supplement producers to consider using CBDV. Science shows that it is especially good for brain health, preventing seizures and autism spectrum disorders.

Of course, quite like CBD, one may also use it for anxiety, depression, pain, sleep issues, and stress reduction. It is also suitable for joint pains, gut inflammatory conditions, nausea, etc.

At present, it is not clear how it mixes with CBD in more significant amounts. It could be a direction for future research. In some cannabis plant species, both CBD and CBDV are present in abundance. Thus, there is no doubt that both will mix well. However, science needs to explore the unique health effects of using CBD and CBDV in higher dosages.

To conclude, there are more than 60 known cannabinoids in the cannabis plant, and the structure of many of these cannabinoids is well known. Science has also explored the health effects of many of these cannabinoids. Some of the cannabinoids share CBD properties, but others are quite different.

CBD is now quite popular, and people know its health benefits. However, many other cannabinoids like CBDV remain neglected. Nonetheless, things are changing fast. The significant interest of the pharma industry in this molecule only shows that it is quite effective in certain disease conditions.

However, supplement producers do not essentially need to wait for the results of these studies, and they can start offering products with other cannabinoids for added health benefits to consumers.

If you want to learn more about CBDV and how it can help create a unique CBD product offering, contact us, and we would be glad to discuss it.

CBD in Malta Everything You Need to Know

News from the end of 2021 suggests that even recreational cannabis is legal in Malta now, but the truth is much different. Things are still in the early stages, and ground realities differ.

It appears that all has been decided, and CBD has been legalized in all the EU countries. However, that is far from true. When it comes to CBD, EU nations failed to have a united approach. It is because many governments have been wary about legalizing CBD despite its proven safety.

Perhaps the problem is in past experiences. Cannabis extracts have been illegal for so many decades that changing the legal framework surrounding them requires time and effort. However, it also seems that there is low awareness about CBD in Malta and thus fewer efforts to legalize it.

The issue is that even if the EU legalizes any substance, it is up to the member states to implement those laws and norms. Moreover, member states may not observe all the EU recommendations, as they might use other local laws like a substance posing a health threat, or so on.

Many nations legalized CBD almost a decade ago when it comes to the EU. However, with time, laws became more mature. And in 2021, the EU finally came up with a robust recommendation making CBD a novel food. This would regulate the market and provide better quality and safer products to consumers.

Additionally, in 2020, the EU court has ruled that all other EU member states are bound to accept CBD as legal if it has been legally produced and sold in other member states.

So, don’t all the EU-wide laws and rulings make CBD legal in Malta? Well, not essentially, and things are more complex.

CBD in Malta, is it legal?

CBD in Malta: Everything You Need to Know

To keep it straight, CBD is not entirely legal in Malta due to the different approaches of the Maltese government. It has failed to comply with various EU norms.

It does not mean that EU norms do not apply to the nation. But, nonetheless, selling or using CBD may still get one into legal trouble. Of course, one may escape persecution by fighting a court case, but that will be a significant headache.

It is difficult to believe that someone may get into trouble for selling or buying CBD oil in a nation that has been trying to become the first EU state to legalize recreational marijuana.

Yes, it has already taken some steps in this direction. But, then, the latest reports show that things on the ground differ, and many laws are still on paper and not implemented on the ground.

A Brief History of Malta Cannabis Laws

Malta is a small nation and has a conservative approach toward the CBD. The CBD legalization movement has never been very strong in the country. Population-based surveys show that no more than one-fourth of the population has some understanding of CBD, which is relatively low.

So, buying CBD has always been a hassle in the tiny nation. Though it is legal to buy CBD in Malta, the process is still so complicated that it is almost impossible to complete the process. In Malta, buying legal CBD is more complex than medical marijuana in many nations.

In Malta, one cannot just go to the pharmacy and buy CBD. Of course, online platforms sell CBD, but that is not legal in the nation. In Malta, buying CBD still needs a doctor’s prescription.

However, it is not as simple as getting a prescription, and there is a complex procedure. Thus, one needs to request a drug control card from a doctor, which tells the ministry of health that a person is planning to use psychoactive agents, though CBD is not a psychotropic drug.

After that, one also has to apply for a medical cannabis permit, which may take months. In fact, experience shows that getting medical cannabis permit is very complex and almost impossible.

However, if you get all these documents, a drug control card, and medical cannabis permit, you can get CBD from the pharmacy. But unfortunately, you cannot buy CBD from online platforms.

Adding to the complications is the news that Malta, in December 2021, became the first EU nation to legalize recreational marijuana. However, ground reports suggest that the law is still to be implemented despite being passed by the local parliament and a decree signed by the president.

Is CBD Oil Illegal in Malta?

Yes, it is legal, but not wholly. Thus, buying it from some shop or online platform or importing it can still get you in trouble. For example, there is a report of the arrest of a doctor for giving CBD to his patients to relieve backache.

There is contradicting information regarding the legality of CBD oil in Malta. On one side, it is claiming to be the first nation to legalize recreational marijuana, making possessing 7 grams of it legal. However, ground reports still suggest that people are being arrested or penalized even for CBD oil

So, what do we make out of this contradicting information? Perhaps, we can confidently say that Malta is on the verge of the biggest change in its history. Soon, CBD products would be completely legal in the nation, including CBD oil.

Not only that, the nation has already ratified the law legalizing recreational marijuana possession and even growing a few plants of it.

However, the problem remains due to some loopholes and deficiencies in the legal system. These deficiencies have still to be addressed. Nevertheless, it is quite likely that things will change considerably in the coming few months. By the end of 2022, not only CBD oil but even recreational marijuana would be legal to buy, possess, and use in the nation.

CBD oil in Malta

Can I Take CBD Oil to Malta?

There is still some confusion regarding the legality of CBD oil in Malta despite significant changes in the legal structure. Theoretically, it is legal to take CBD to Malta if the product is of EU origin or was legally purchased in another EU nation.

Moreover, the latest changes suggest that even recreational marijuana will become legal in the nation.

However, a word of caution, reports like an arrest of a doctor for dispensing CBD products to his patients suggest that ground realities differ. Despite the legal orders, implementation of these legal changes still remains an issue.

Nevertheless, it would be safe to say that Malta is on the verge of significant change, and CBD oil, perhaps even recreational marijuana, would be completely legal to possess and use in the nation by the end of 2022.

If you are interested in starting your CBD business in Malta, we can help you out with it.

 

How CBD & Immune Systems Interact

The human immune system is quite complex, and it saves the body from invaders like bacteria, viruses, and fungi. It also helps in tissue repair and may also help eliminate toxic substances from the body.

It is quite a complex system containing specialized organs, cells, and proteins. The human system is continually growing and upgrading. It is created in the bone marrow, may mature in various organs, travel through a dedicated highway called the lymphatic system, and quickly acts where needed most.

If some threat is detected, it initiates a defensive response in many ways. It may attack and kill the invading microprobe, create proteins that kill the invading microorganisms, and more. It also releases messenger proteins to get support from various organs. Thus, it plays a vital role in inflammation and tissue regeneration.

The immune system contains two parts: the innate immune system with which a person is born and the adaptive immune system that develops throughout life. Both these immune systems share information with each other and work together to protect the human body.

Some organs that play a vital role in its development are bone marrow, lymph nodes, adenoids, spleen, thymus, and tonsils.

Although primarily protective, it is also prone to errors. For example, sometimes, it may hyper-react, causing allergic reactions and damage to the body. Similarly, it may also sometimes initiate inflammation responses that do more harm than good. Thus, a need to tweak and modulate human immunity.

CBD has many health effects, and many of its benefits are due to its influence on the immune system.

CBD and immunity

How CBD & Immune Systems Interact

Considering that the immune system is quite complex, it isn’t easy to understand how it interacts with immunity. Nonetheless, science is still trying to understand how it may help the human immune system.

CBD is not a nutrient, but it can modulate various receptors, enzyme systems, and organs and thus ultimately change the immune responses.

Perhaps the most important way it acts is due to its effect on the endocannabinoid system. It appears that CBD is structurally close to intrinsic endocannabinoids, and thus it may affect endocannabinoid receptors present throughout the human body.

Before discovering the endocannabinoid system, researchers were genuinely struggling to explain how CBD may affect the immune system. Medical researchers could see that CBD can alter immune responses, but they could not explain how it works. Unlike another compound in cannabis, THC, CBD does not have potent mind-altering properties.

However, it may alter immune responses by modulating the working of endocannabinoid receptors present throughout the body. Now science shows that endocannabinoid receptors are not just present in the brain but also in every organ from the gut to the skin.

CBD can modulate the activity of CB1 receptors that are primarily found in the brain and CB2 receptors that are more abundant in various body organs.

However, there are other ways in which CBD may affect the immune system. For example, studies show that it can act as an antioxidant and thus help change the body’s redox balance. Now researchers think that its ability to modulate redox balance plays a critical role in its anti-inflammatory properties.

Does CBD Help Immune System Response?

CBD can alter immune responses. The immune system has many complex functions in the body. Thus, sometimes it appears to suppress immunity, while it seems to modulate immune responses in other instances.

However, one should not be worried about hearing that it may also suppress immunity. Most anti-inflammatory medications work by suppressing certain functions of immunity. Similarly, CBD also reduces some overactive parts of the immune system.

Of course, since it can suppress immunity, it is pretty good for reducing pain and inflammation. However, quite like other anti-inflammatory drugs, one should be careful using CBD when there is a high risk of catching an infection.

Nonetheless, it is more likely to modulate immune responses, as visible by its effect on various disorders. In addition, it means that it is more likely to suppress only specific immune responses selectively. Thus, it would not increase the risk of seasonal infections or make a person prone to certain diseases.

Perhaps the best way in which CBD helps the immune system is by suppressing hyperinflammatory responses. Thus, it is good for conditions like joint pains. Additionally, it may also lower systemic inflammation, and help prevent disorders caused by low-grade inflammation like heart diseases or neurodegenerative disorders.

New studies show that it may alter certain immune responses more than others. Although researchers are not sure how it happens, they think that its ability to suppress certain parts of immunity selectively may significantly help in some conditions. Thus, early experimental studies show that CBD may help prevent type 1 diabetes, an autoimmune disorder.

Studies suggest that the endocannabinoid system and cannabinoid receptors are involved in the development of autoimmune disorders. It also means that suppressing specific immune responses and modulating the working of CB1 and CB2 receptors may be particularly helpful in autoimmune conditions.

CBD and immune system

List Some Ways CBD Interacts with Immunity

In this article, we have already mentioned many ways in which CBD may interact with immunity. CBD may not boost the immune system, but it may help fine-tune immune responses. Thus, it can help in many disease conditions.

The most important way in which it interacts with immunity is through its influence on the endocannabinoid system and its ability to modulate CB1 and CB2 receptors. These receptors are present in all immune organs, from bone marrow to the lymph tissues.

Some of the effects of CBD on immunity are indirect. Like it may promote the working of other internal organs and thus help normalize immunity.

There is no doubt that another significant interaction pathway is its effect on redox balance. In addition, CBD can boost the body’s antioxidant ability and thus help alter immune responses.

Further, some of its influences on immunity may likely be due to its effect on brain health. For example, it may alter immunity by reducing stress, lowering the level of stress hormones, and much more.

Benefits of CBD As an Immunosuppressant

Most people do not realize that significant overexpression of certain parts of the immune system is a significant problem. This is because the immune system often wrongly starts targeting various body parts or overreacting. This is visible in conditions like inflammatory disorders of joints or autoimmune diseases.

Consequently, there could be many benefits of the mildly suppressing immune system with the help of CBD. Moreover, unlike medications, its action is much more subtle and selective. Pharmacological immunosuppressants are highly toxic, causing suppression of even beneficial immune cells.

However, unlike medications, CBD only suppresses some overactive parts of the immune system through the endocannabinoid system. It is more like a balancing act. Thus, it would not suppress the immune system significantly, but only enough to help in a range of disease conditions.

Due to its ability to suppress immunity, CBD may help with inflammation. Therefore, it is suitable for autoimmune conditions like type 1 diabetes, multiple sclerosis, lupus, allergies, and much more.

What is good about CBD is that it also has many other health effects. Hence, it not only helps overcome autoimmunity but may also help counter some of the autoimmunity-associated problems like spasticity, skin irritation, pain, mood swings, and much more.

Final thoughts

CBD can influence the immune system in many ways. Firstly, it may directly influence the working of immune cells, alter the activity of immune organs, and may also help due to its effect on the body’s redox system. Moreover, CBD is safe for prolonged and regular use. It may suppress only overactive parts of the immune system and thus help in allergies, inflammation, and autoimmunity without posing any health threat.

If you are interested in learning more about CBD or want to help people living with immune disorders, we have many CBD products.

What Are Some Lesser-Known CBD Health Benefits?

For those skeptical about CBD and its health benefits, it is good to know that humans have traditionally used cannabis to treat health disorders for thousands of years. However, it was wrongly banned in the mid-20th century over the worries of addiction and harm to health.

Fortunately, medical experts started realizing their mistakes by the end of the 20th century. They understood that CBD is relatively safe and suitable for health. In addition, science revealed that most harms and addictions are due to THC in cannabis, and removing THC from CBD products makes any cannabis product highly safe to consume.

Some Lesser-Known CBD Health Benefits

Those who still disbelieve in CBD need to understand that there are already few approved medical drugs based on CBD. It is good to treat resistant epilepsy in children, rare autoimmune neurological disorders, have a calming effect, and may also help with some mental health issues. Thanks to extensive clinical research into the subject, the list of its benefits is fast expanding.

In recent years, there has been increasing interest in finding natural remedies for metabolic disorders and some less common diseases. Studies show that CBD can help in the least expected way. Thus, it could be good for gut health, alter immune responses, fight infections, manage autoimmune disorders, suppress inflammation, etc.

It is impressive that CBD also appears to be good for conditions like diabetes, rheumatoid arthritis, substance abuse disorder, weight loss, and even more.

lesser known CBD benefits

What Are Some Well-Known Health Benefits of CBD?

Seizures

It could be regarded as one of the less unexpected benefits of CBD. But now, studies show that CBD is quite suitable for controlling seizures when used along with other treatments.

Even more striking are the findings indicating that CBD is especially good for resistant epilepsy. Moreover, these are the patients who failed to get benefits from some of the best pharmacological drugs. However, adding CBD to treatment may considerably reduce seizure rates.

Studies show that adding CBD to traditional anti-epileptic therapy in those resistant to other treatments may benefit about half the patients (49%), which is much higher than placebo. Thus the study leaves little doubt about its efficacy.

Therefore, US FDA and European Medical Agency (EMA) have even approved CBD-based medication called Epidyolex to manage this rare kind of resistant seizure disorder.

But that is not all; amazingly, it is approved for use in children. This only shows that CBD is relatively safe for use in different age groups.

Pain

It is another area of interest. People have traditionally used cannabis or marijuana to manage severe and chronic pains. Of course, CBD is different from cannabis or marijuana, but it seems to retain some of its pain-killing action. In addition, it appears that broad-spectrum CBD is more effective in pain management than CBD isolate.

When using CBD for pain, one is not expected to use it alone and instead as a part of broader therapy. Thus, it may be combined with other medications and pain killers, and it will potentiate their action.

Diabetes

Again, do not expect CBD to prevent or manage diabetes alone, as it is not a magic pill. However, it can be pretty good when used along with other efforts, lifestyle interventions, and medications.

Studies show that it can modulate metabolism and appetite and reduce insulin resistance. Thus, regular intake of CBD may help prevent diabetes in a high-risk individual. It is also beneficial for those living with mild to moderate diabetes.

Diabetes is quite a complex disorder, and CBD can help in multiple ways. For example, CBD may help lower the risk of various diabetes-associated complications. In addition, it may help both due to its mild glucose-lowering action and its ability to reduce bad cholesterol, reduce chronic inflammation, and help regulate insulin secretion.

Not only that, those living with diabetes are prone to neuropathies, and CBD may help prevent and manage nerve disorders. It may be good for preventing diabetes retinopathy, too.

Neurodegenerative diseases

Do not expect CBD to treat Alzheimer’s or Parkinson’s. However, CBD can help reduce the risk of these ailments on prolonged use. It may have a role in slowing down the progress of these disease conditions. Additionally, it may also help manage some of the symptoms of neurodegenerative disorders.

Studies suggest that CBD may help in many ways. It can lower inflammation, alter immune responses, and may also help due to antioxidants. Further, it benefits due to its impact on the endocannabinoid system and modulating CB1 and CB2 receptors. Studies show that it may also influence cellular energy production, increase the production of neurotransmitters, and thus help in multiple ways.

Multiple sclerosis (MS)

MS is a chronic and a pretty common autoimmune disorder of the brain. It is highly challenging to treat. Some people do not respond to immunomodulatory therapy. Even worse, immunomodulatory drugs are highly toxic. However, CBD may help as an addon therapy by modulating immune responses1.

But that is not all, and it appears that CBD may also help tackle some of the symptoms of MS. Thus, it may help reduce MS-associated spasticity.

CBD is so good for managing MS that EMA has already approved CBD-based medications to help those living with MS. It is a medication called Sativex.

Anxiety

Anxiety is the most common emotional disorder that affects most people sometimes in their lives. Since it is such a common health issue, people often use natural supplements to manage the condition. Studies show that CBD may be good to use in mild to moderate anxiety. It may help overcome worries and fears.

Depression

Depression is another common mood disorder. It may even coexist with anxiety. Although there are many medications to manage depression, they are highly toxic. Moreover, studies show that pharmacological drugs only work in severe depression, but they fail to help in mild to moderate cases. Therefore, studies suggest that CBD could be one of the better and more natural ways of managing depression.

Insomnia

Sleep disorders are on the rise. They are now considered an independent risk factor for various ailments. It appears that people are not only sleeping less, they also have poor sleep quality. Further, the use of gadgets is making things worse. Many people may lie in bed for long, but they do not sleep enough.

Sedative drugs may help initiate and maintain sleep, but they alter the sleep architecture. Thus, people taking sleeping pills do not wake up feeling fresh the following day. However, CBD does not alter sleep architecture and works mildly.

Inflammation and Autoimmunity

Low grade or so-called silent inflammation is among the significant cause of the chronic disorder. It appears that CBD may not only help subdue inflammation but may have a role in altering inflammatory responses. Thus, CBD may help prevent flares of autoimmune conditions, too.

Acne

Many countries now allow CBD supplement producers to claim that their product is anti-sebum and may help prevent acne. There is emerging evidence that CBD may play a vital role in managing acne. It helps both due to its ability to reduce sebum production and its anti-inflammatory properties. In addition, it is quite likely that it may help due to other mechanisms. CBD work by modulating the endocannabinoid system that is present widely in the skin.

cbd health benefits and lesser known effects

Is CBD an Anti-Inflammatory?

Yes, it works. In recent years researchers have discovered many mechanisms in which CBD may work. CBD can bind to various receptors and alter inflammatory responses. It seems that CBD is suitable for both local acute inflammation like that found in joint pains and low-grade inflammation that causes chronic disorders. It may also help in autoimmune conditions due to its anti-inflammatory properties.

Is CBD Antifungal?

CBD oil can exert potent antifungal infection in many ways. Generally, most oils have mild antifungal properties. However, new studies now suggest that CBD has direct antimicrobial properties. Thus, it may help both when used orally or applied topically.

However, it may not help in severe systemic fungal infections and is more likely to help well with some localized fungal infections. Nonetheless, there is a need for more studies to explore its role in controlling fungal infections.

Does CBD Oil Have Antibacterial Properties?

CBD has mild antibacterial properties. It works in multiple ways. It has some direct antimicrobial action. However, it may also work due to its influence on immunity, ability to reduce inflammation, and much more

To conclude, CBD is no panacea, but it can definitely help with many health conditions. People have traditionally used CBD to manage all kinds of disease conditions. Some of its benefits, like those in pain, anxiety, and seizures, are well known. However, new studies show that it may also help lower inflammation, help in autoimmune conditions, normalize metabolism, and may even help prevent and manage infectious diseases. It is pretty likely that many of its benefits are still waiting to be discovered.

Those interested in starting their CBD business or interested in creating unique CBD products for various health conditions can contact us. You can also learn more about CBD oil health benefits here or buy CBD products wholesale.