What are the health benefits of CBD oil?

The mass influx of CBD-related information injected into the public’s consciousness has blurred the lines between what’s factually correct and factually incorrect, especially when it comes to CBD’s supposed health benefits.

Unfortunately, many companies and brands out there cherry-pick studies to suit their own sales and marketing narrative. These studies are often too old, inconclusive, or irrelevant. We’ve even seen some studies used that aren’t even applicable to what’s being said. 

This is something we at Essentia Pura want to rectify. We believe in the strength of reliable studies on what high-quality CBD oil may do for you. We don’t believe in deceiving you with bogus, unsubstantiated claims. 

With this in mind, let’s dig into what the studies are saying about CBD oil.

What can CBD oil be used for?

While we’re not at liberty to recommend any of CBD oil’s uses for health and wellness symptoms you may be facing, we can look at the studies surrounding its potential health benefits.

Anecdotally, many users around the world claim CBD oil has helped them alleviate symptoms of pain (short-term, chronic, or otherwise), inflammation, anxiety, and insomnia, improve their gut health, as well as feeling overall health and wellness benefits. 

Anecdotal evidence, unfortunately, doesn’t hold much water here. Scientifically-backed studies and research, however, does. 

Let’s look at what we know so far. Note: A detailed summary of CBD oil for pain and CBD oil for skin care can be found in the sections below.

CBD interacts with your endocannabinoid system (ECS) to kickstart the supposed physiological benefits

CBD is a clever cannabinoid. It interacts with what’s known as your endocannabinoid system (ECS), a naturally occurring biological system in all mammals composed of cannabinoid receptors, endocannabinoids, and enzymes. 

Read more: What are Endocannabinoids

This trio of components helps regulate your body’s internal core functionality to bring your body to a state of physiological equilibrium — or, rather, homeostasis. 

The primary functions they regulate include but are not limited to:

  • Mood
  • Sleep
  • Appetite
  • Stress
  • Inflammation
  • Reproductive functionality
  • Cognitive thinking and processes

Your cannabinoid receptors are a very important component of your ECS. They’re found in many parts of the body and are separated into two types: cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2)

The former is primarily located in many regions of the brain and central nervous system (CNS), whilst the latter is primarily located in the spleen, liver & bone cells, and throughout your immune system. 

Many people believe CBD acts the same way as tetrahydrocannabinol (THC) insofar as binding directly to your cannabinoid receptors to produce desired effects (getting you high or stoned in THC’s case). This isn’t strictly true.

You see, CBD interacts with your entire ECS in a much different way. It doesn’t bind to either receptor at all. Instead, it targets other receptor sites around the body, namely vanilloid receptors (TRPV1) and serotonin receptors (5-HT1A)

This, alone, is thought to kickstart CBD’s benefits within your body.

CBD oil may alleviate symptoms of anxiety and anxiety-related disorders

Anxiety is the most common mental health problem in Europe. Approximately 25 million people across 28 EU states live with an anxiety disorder. This is a huge number of people (approximately 5.4% of the EU population) and many of them face the debilitating and life-altering symptoms associated with it. 

Fortunately, there are numerous compelling studies out there suggesting CBD oil may have anti-anxiety qualities. 

In 2015, researchers studied CBD oil for anxiety on rodent test subjects. They discovered it reduced anxiety and stress-related symptoms, particularly behavioural ones. They also realised a decrease in heart rate after consumption.

CBD has proven anti-epileptic qualities

One of the most remarkable discoveries was (and still is) CBD’s effectiveness in combating two rare forms of epilepsy: Lennox-Grasaut syndrome and Dravet Syndrome. 

In 2018, GW Pharmaceuticals released a purely CBD-based drug called Epidiolex, one of the first cannabis-based drugs to be given the FDA stamp of approval in the United States. 

The clinical studies leading up to the release was fascinating to follow. Researchers discovered the administration of Epidiolex significantly reduced seizure frequency and intensity in both types of epilepsy. 

In 2019, the European Medicines Agency (EMA) gave Epidiolex marketing approval. Further clinical trials are now underway to understand its effectiveness against anxiety, Parkinson’s disease, and psoriatic arthritis.

The benefits of CBD oil for pain relief

At some point or another, everyone walking the earth experiences pain. It’s just a simple fact of life. Some experience a large number of short-term pain symptoms, whilst others experience long-term chronic, oftentimes debilitating pain. 

Thankfully, there are some studies on CBD oil for pain and they’re extremely promising.

CBD oil may help with arthritic pain

Across Europe, approximately 40 million people suffer from arthritis. This is a huge number of people — nearly the same number of people living in Poland. 

Luckily, CBD may have some effect on arthritis and its symptoms. 

In 2017, researchers injected rodent test subjects with 3mg of sodium monoiodoacetate to induce osteoarthritis symptoms. They then applied localised CBD treatment (100-300 micrograms) to the affected area and discovered reduced inflammation and pain, as well as decreased later-stage nerve damage. 

This research isn’t a clinical trial, however. No humans were tested on.

CBD oil has the potential to alleviate multiple sclerosis (MS) induced muscle spasms

One of the biggest breakthroughs for cannabis-derived medicinal drugs happened back in 2010. GW Pharmaceuticals, a prolific pharmaceutical company based in the UK, released Nabiximols (Sativex), an oral spray containing both CBD and THC for symptoms of multiple sclerosis. 

Multiple clinical trials leading up to its release were (and still are) fascinating. Adults with MS reported short-term alleviation of muscle spasticity (muscle stiffness and tightness) after Sativex use. 

Sativex isn’t perfect, however. Italian researchers collected data from 30 MS centres across the country. Out of 1597 patients using Sativex, 631 (39.5%) discontinued treatment after four or six weeks of treatment. The two primary reasons for treatment discontinuation were lack of effectiveness (23.2%) and adverse side effects of CBD and THC (16.3%).

The benefits of CBD oil for your skin

Similar to pain, everyone on earth has experienced skin complaints. It’s a perfectly normal, natural part of life. However, there are times when skin complaints can be psychologically troubling and physically painful, especially when they’re long-term and chronic.

There is some good news on the horizon, though. Studies into CBD for skincare are very promising (but quite limited).

CBD may reduce signs of acne

CBD topicals and skincare products, in general, aren’t designed to penetrate the bloodstream. They’re designed to positively affect surface area skin issues, as well as potentially soothe aching muscles and joints. 

CBD is known to actively affect sebocytes, which are cells found in sebaceous glands. These glands produce sebum, an oily, waxy substance that helps your skin feel soothed and moisturised. If you produce too much sebum, it may cause acne. 

Research suggests CBD can absorb into your sebaceous glands via hair follicles resulting in less sebum production and potentially less acne

CBD may also absorb below the skin’s surface and interact with nearby cannabinoid receptors in your sebaceous tissue and nerve fibres. A 2005 study believes this interaction may cause anti-inflammatory benefits

If you’d like to know more about what CBD could do for you and your body, please don’t hesitate to contact us. Our friendly staff will answer any questions you have about what we’ve written here. We’re also on-call to answer any questions about our own Premium CBD Oils and what they can do for you.

What is CBD Oil?

Cannabidiol oil (otherwise known as CBD oil) is the stuff everyone’s talking about right now. It’s everywhere. All over the internet, in your local grocery stores, and on the shelves of your favourite head shops — you can even find them in petrol stations, pharmacies, and beauty stores. 

But what exactly is CBD oil and why is there so much hype surrounding it?

CBD oil is made from extracts taken directly from varieties of cannabis (in our case hemp). 

The extracts are diluted in carrier oils such as hemp seed oil, medium-chain-triglyceride (MCT) oil, sunflower oil, or avocado oil — this, of course, gives the product its distinct oily liquid texture. Other beneficial ingredients are sometimes included in the formulas too e.g. melatonin for enhanced sleep benefits.

There are three primary extract types used in CBD oils:

  • Isolatecontains only CBD and no other beneficial plant compounds 
  • Broad-spectrumcontains a wide range of cannabinoids, terpenes, flavonoids, and other beneficial plant compounds (minus tetrahydrocannabinol (THC))
  • Full-spectrumcontains the “full” range of cannabinoids, terpenes, flavonoids, and other beneficial plant compounds (including THC)

The most popular extract is full-spectrum. Consumption of CBD oils carrying full-spectrum hemp extracts causes the entourage effect, a phenomenon where each plant compound works synergistically within your body to provide a wider range of benefits (at least in theory). 

But what are the health benefits of CBD and CBD oils?

What are the potential health benefits of CBD oil?

While we’re not at liberty to make bold and outrageous claims about the health benefits of CBD oil, we can look at the studies surrounding it.

There are a number of existing studies on:

  • CBD oil for pain 
  • CBD oil for anxiety
  • CBD oil for rare forms of epilepsy
  • CBD oil for multiple sclerosis (MS)
  • CBD oil for arthritis

Each of the studies and corresponding research results is incredibly compelling.

CBD has the potential to relieve pain and pain-related symptoms

CBD cleverly interacts with your endocannabinoid system (ECS), a naturally-occurring biological system found in all mammals composed of cannabinoid receptors, endocannabinoids, and enzymes. 

Together, this trio helps regulate a large number of your body’s core functions such as sleep, mood, appetite, stress, memory, inflammation, and cognitive thinking. This regulation of core functionality is said to result in internal physiological equilibrium, otherwise known as homeostasis. 

There’s a common misconception that CBD directly binds to your cannabinoid receptors. It doesn’t. Researchers and cannabis experts believe it behaves in a much different way.

In a recent 2018 review on CBD oil for pain and pain management, the author looked at research and studies spanning across 48 years. 

He notes CBD may help manage and regulate pain and pain perception by interacting with a number of different receptor sites without directly activating either cannabinoid receptors. The receptor sites include:

  • Serotonin 1A receptor (5-HT1A) 
  • Ion channels — vanilloid receptor (TRPV1), TRPA1, TRPM8, and the glycine receptor (GlyR)
  • Peroxisome proliferator-activated receptors (PPARs)

CBD’s interaction with serotonin receptors, for example, may induce analgesic effects. Similarly, its activation of the vanilloid receptor promotes an antihyperalgesic effect, thus lessening pain sensitivity and pain perception (in rodent test models).

CBD has proven effectiveness against rare forms of epilepsy

CBD for epilepsy and epilepsy-induced seizures is well-documented and widely recognised.  

Epidiolex, a CBD based drug designed and manufactured by British pharma company GW Pharmaceuticals (now Jazz Pharmaceuticals), was released back in 2018. It gained marketing approval from the European Medicines Agency (EMA) later in 2019.

The drug, which comes in the form of an oral solution, specifically targets seizures associated with Lennox-Gastaut syndrome (LGS) and Dravet syndrome — all rare forms of epilepsy. 

Currently, there are a number of clinical trials underway to examine Epidiolox’s effectiveness against anxiety, Parkinson’s disease, and psoriatic arthritis.

CBD may help with anxiety and anxiety-related symptoms

Anxiety comes in many forms. Some cases are mild; others are more severe. Many patients often use traditional pharma medicines alongside conventional therapy such as cognitive behavioural therapy (CBT) and hypnotherapy. 

However, there’s some scope to suggest that CBD oil for anxiety may be a viable alternative. 

A 2018 review of several clinical studies show CBD may have antipsychotic effects on people with schizophrenia and a substantial effect on people with a generalised anxiety disorder (GAD). 

What are the possible side-effects of CBD oil?

Side-effects of CBD oil are typically very mild and noticeably subtle — you probably won’t experience any at all (aside from some fatigue and drowsiness in high doses if you’re a first-time user). 

The short-term side-effects of CBD oil are:

  • Drowsiness
  • Lightheadedness 
  • Fatigue
  • Appetite change
  • Weight changes
  • Nausea & vomiting (in extreme and severe cases)

Long-term side effects, on the other hand, are relatively unknown. Very few (if any) long-term or chronic CBD usage studies exist.

Other side-effects consider before consuming CBD oil

You should approach mixing CBD and certain medications with some caution. Research shows CBD may interact with cytochrome P450, a system within your liver composed of vital enzymes that form or breakdown certain molecules. 

CBD’s interaction with the cytochrome P450 system is said to inhibit two specific enzymes: CYP3A4 and CYP2D6.

CYP3A4 is responsible for the metabolism of

  • Lipitor
  • Xanax
  • Claritin
  • Viagra
  • Ambien 
  • Topamax 
  • Fentanyl
  • Prednisone

CYP2D6 is responsible for the metabolism of:

CBD, therefore, potentially lessens the effects of each drug listed above. Always consult your doctor or general practitioner before taking CBD with other medications.

How is CBD oil made?

Before CBD oil can be made, the variety of cannabis—in our case hemp—needs to be grown and cultivated. 

As soon as the hemp is nice and healthy, it’s harvested ready for extraction. We personally always use organic pesticide and herbicide-free hemp biomass from carefully selected regions in Italy known for their excellent hemp quality. 

Our extraction process is meticulous. We use technologically-advanced closed-loop supercritical CO2 extraction techniques, ensuring clean, solvent-free hemp extract (also known as “crude extract”). 

Once extraction is complete, we can further process and tailor the resulting crude extract to suit your needs and requirements. Our Premium CBD Oil Drops, for example, can be decarboxylated and de-waxed before being diluted into your chosen carrier oil. 

Sounds pretty awesome, right?

Well, if you’d like to know more about our CBD oils, how they’re made, and what they can do for you, please don’t hesitate to contact us here. Our friendly staff is more than happy to help you out.